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5hld

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==E. coli PBP1b in complex with acyl-CENTA and moenomycin==
==E. coli PBP1b in complex with acyl-CENTA and moenomycin==
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<StructureSection load='5hld' size='340' side='right' caption='[[5hld]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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<StructureSection load='5hld' size='340' side='right'caption='[[5hld]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5hld]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HLD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5hld]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HLD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=63V:(2S)-5-METHYLIDENE-2-{(1R)-2-OXO-1-[(THIOPHEN-2-YLACETYL)AMINO]ETHYL}-5,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC+ACID'>63V</scene>, <scene name='pdbligand=M0E:MOENOMYCIN'>M0E</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hl9|5hl9]], [[5hla|5hla]], [[5hlb|5hlb]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=63V:(2S)-5-METHYLIDENE-2-{(1R)-2-OXO-1-[(THIOPHEN-2-YLACETYL)AMINO]ETHYL}-5,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC+ACID'>63V</scene>, <scene name='pdbligand=M0E:MOENOMYCIN'>M0E</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mrcB, pbpF, ponB, b0149, JW0145 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hld OCA], [https://pdbe.org/5hld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hld RCSB], [https://www.ebi.ac.uk/pdbsum/5hld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hld ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hld OCA], [http://pdbe.org/5hld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hld RCSB], [http://www.ebi.ac.uk/pdbsum/5hld PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hld ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PBPB_ECOLI PBPB_ECOLI]] Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
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[https://www.uniprot.org/uniprot/PBPB_ECOLI PBPB_ECOLI] Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5hld" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5hld" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
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[[Category: King, D T]]
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[[Category: Large Structures]]
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[[Category: Strynadka, N C.J]]
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[[Category: King DT]]
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[[Category: Inhibitor complex]]
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[[Category: Strynadka NCJ]]
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[[Category: Penicillin-binding protein]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Transglycosylase]]
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[[Category: Transpeptidase]]
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Current revision

E. coli PBP1b in complex with acyl-CENTA and moenomycin

PDB ID 5hld

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