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5hyt

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==Structure of human C4b-binidng protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M22 protein==
==Structure of human C4b-binidng protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M22 protein==
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<StructureSection load='5hyt' size='340' side='right' caption='[[5hyt]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
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<StructureSection load='5hyt' size='340' side='right'caption='[[5hyt]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5hyt]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5hyt]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HYT FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hyu|5hyu]], [[5hyp|5hyp]], [[5hzp|5hzp]], [[5i0q|5i0q]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyt OCA], [http://pdbe.org/5hyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hyt RCSB], [http://www.ebi.ac.uk/pdbsum/5hyt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyt ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyt OCA], [https://pdbe.org/5hyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hyt RCSB], [https://www.ebi.ac.uk/pdbsum/5hyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
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[https://www.uniprot.org/uniprot/Q54901_STRPY Q54901_STRPY]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bahn-Suh, A J]]
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[[Category: Homo sapiens]]
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[[Category: Buffalo, C Z]]
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[[Category: Large Structures]]
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[[Category: Ghosh, P]]
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[[Category: Streptococcus pyogenes]]
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[[Category: Complement]]
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[[Category: Bahn-Suh AJ]]
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[[Category: Hypervariable antigen]]
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[[Category: Buffalo CZ]]
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[[Category: Immune system]]
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[[Category: Ghosh P]]
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[[Category: M protein]]
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[[Category: Streptococcus pyogene]]
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Current revision

Structure of human C4b-binidng protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M22 protein

PDB ID 5hyt

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