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5hyu

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==Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M2 protein==
==Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M2 protein==
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<StructureSection load='5hyu' size='340' side='right' caption='[[5hyu]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
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<StructureSection load='5hyu' size='340' side='right'caption='[[5hyu]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5hyu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5hyu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HYU FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hyp|5hyp]], [[5hyt|5hyt]], [[5hzp|5hzp]], [[5i0q|5i0q]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.561&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyu OCA], [http://pdbe.org/5hyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hyu RCSB], [http://www.ebi.ac.uk/pdbsum/5hyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyu OCA], [https://pdbe.org/5hyu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hyu RCSB], [https://www.ebi.ac.uk/pdbsum/5hyu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/M21_STRPY M21_STRPY]] This protein is one of the different antigenic serotypes of protein M. Protein M is closely associated with virulence of the bacterium and can render the organism resistant to phagocytosis. [[http://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
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[https://www.uniprot.org/uniprot/M21_STRPY M21_STRPY] This protein is one of the different antigenic serotypes of protein M. Protein M is closely associated with virulence of the bacterium and can render the organism resistant to phagocytosis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5hyu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5hyu" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[M2 protein|M2 protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bahn-Suh, A J]]
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[[Category: Homo sapiens]]
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[[Category: Buffalo, C Z]]
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[[Category: Large Structures]]
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[[Category: Ghosh, P]]
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[[Category: Streptococcus pyogenes]]
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[[Category: Complement]]
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[[Category: Bahn-Suh AJ]]
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[[Category: Hypervariable antigen]]
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[[Category: Buffalo CZ]]
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[[Category: Immune system]]
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[[Category: Ghosh P]]
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[[Category: M protein]]
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[[Category: Streptococcus pyogene]]
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Current revision

Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M2 protein

PDB ID 5hyu

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