PDZ and LIM domain protein

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(New page: <StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin '(PDB entry 2pa1)' scene=''> ...)
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<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''>
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== Function ==
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'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure<ref>PMID:17767364</ref>.<br /> For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZIC:Enigma Family]].
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<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin '(PDB entry [[2pa1]])' scene=''>
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*'''PDLIM1''' promotes cell attachment at the cytoskeleton. For details see [[Group:MUZIC:ALP]].<br />
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*'''PDLIM2''' may have a role in bringing proteins to the cytoskeleton.<br />
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'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure. For details on PDLIM1 see [[Group:MUZIC:ALP]].
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*'''PDLIM3''' may have a role in organizing actin filament arrays within muscle cells.<br />
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*'''PDLIM4''' is a Zn+2 ion binding protein.<br />
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*'''PDLIM5''' has important role in heart development by scaffolding PKC to the Z-disk region.<br />
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*'''PDLIM7''' is an adaptor protein localizing the LIM-binding proteins to muscle tissues.<br />
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==3D structures of PDZ and LIM domain protein=
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== Relevance ==
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PDLIM2 may contribute to cancer cells migratory capacity. PDLIM5 overexpression promotes the development of heart hypertrophy.<br />
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</StructureSection>
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==3D structures of PDZ and LIM domain protein==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*PDLIM1
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**[[2pkt]] – hPDLIM + α-actinin C terminal - human<br />
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**[[1x62]] – hPDLIM LIM domain - NMR<br />
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'''PDLIM1'''
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*PDLIM2
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[[2pkt]] – hPDLIM + α-actinin C terminal - human<br />
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**[[1vb7]] – mPDLIM PDZ domain – mouse - NMR<br />
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[[1x62]] – hPDLIM LIM domain - NMR<br />
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**[[2pa1]] – hPDLIM PDZ domain + β-tropomysin C terminal <br />
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**[[3pdv]] – hPDLIM PDZ domain + influenza virus NS1 C terminal <br />
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'''PDLIM2'''
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*PDLIM3
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[[1vb7]] – mPDLIM PDZ domain – mouse - NMR<br />
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**[[1v5l]] – mPDLIM PDZ domain - NMR<br />
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[[2pa1]] – hPDLIM PDZ domain + β-tropomysin C terminal <br />
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**[[1x64]] – mPDLIM LIM domain - NMR<br />
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[[23pdv]] – hPDLIM PDZ domain + influenza virus NS1 C terminal <br />
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**[[4ydp]] - hPDLIM PDZ domain <br />
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'''PDLIM3'''
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*PDLIM4
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[[1v5l]] – mPDLIM PDZ domain - NMR<br />
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**[[4q2o]] – hPDLIM <br />
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[[1x64]] – mPDLIM LIM domain - NMR<br />
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**[[2v1w]] – hPDLIM + α-actinin C terminal <br />
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**[[2eeg]] – hPDLIM PDZ domain - NMR<br />
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'''PDLIM4'''
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*PDLIM5
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[[2v1w]] – hPDLIM + α-actinin C terminal <br />
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**[[1wf7]] – mEnigma homolog protein PDZ domain - NMR<br />
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[[2eeg]] – hPDLIM PDZ domain - NMR<br />
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**[[2dar]] – hEnigma homolog protein LIM domain - NMR<br />
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**[[2uzc]] – hPDLIM + α-actinin C terminal <br />
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'''PDLIM5'''
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*PDLIM7
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[[1wf7]] – mEnigma homolog protein PDZ domain - NMR<br />
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**[[2q3g]] – hPDLIM PDZ domain + β-tropomysin C terminal <br />
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[[2dar]] – hEnigma homolog protein LIM domain - NMR<br />
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**[[7rm8]] – hPDLIM PDZ domain + SNX17 peptide - NMR <br />
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[[2uzc]] – hPDLIM + α-actinin C terminal <br />
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'''PDLIM7'''
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*PDLIM
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[[2q3g]] – hPDLIM PDZ domain + β-tropomysin C terminal <br />
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**[[1rgw]] – hPDLIM PDZ domain - NMR<br />
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}}
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== References ==
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<references/>
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[[Category:Topic Page]]

Current revision

Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry 2pa1)

Drag the structure with the mouse to rotate

3D structures of PDZ and LIM domain protein

Updated on 21-August-2023

References

  1. ↑ te Velthuis AJ, Bagowski CP. PDZ and LIM domain-encoding genes: molecular interactions and their role in development. ScientificWorldJournal. 2007 Sep 1;7:1470-92. PMID:17767364 doi:10.1100/tsw.2007.232

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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