PDZ and LIM domain protein

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:48, 21 August 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''>
<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''>
-
+
== Function ==
-
'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure. For details on PDLIM1 see [[Group:MUZIC:ALP]].
+
'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure<ref>PMID:17767364</ref>.<br /> For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZIC:Enigma Family]].
 +
 
 +
*'''PDLIM1''' promotes cell attachment at the cytoskeleton. For details see [[Group:MUZIC:ALP]].<br />
 +
*'''PDLIM2''' may have a role in bringing proteins to the cytoskeleton.<br />
 +
*'''PDLIM3''' may have a role in organizing actin filament arrays within muscle cells.<br />
 +
*'''PDLIM4''' is a Zn+2 ion binding protein.<br />
 +
*'''PDLIM5''' has important role in heart development by scaffolding PKC to the Z-disk region.<br />
 +
*'''PDLIM7''' is an adaptor protein localizing the LIM-binding proteins to muscle tissues.<br />
 +
 
 +
== Relevance ==
 +
PDLIM2 may contribute to cancer cells migratory capacity. PDLIM5 overexpression promotes the development of heart hypertrophy.<br />
 +
</StructureSection>
==3D structures of PDZ and LIM domain protein==
==3D structures of PDZ and LIM domain protein==
Line 23: Line 34:
**[[1v5l]] – mPDLIM PDZ domain - NMR<br />
**[[1v5l]] – mPDLIM PDZ domain - NMR<br />
**[[1x64]] – mPDLIM LIM domain - NMR<br />
**[[1x64]] – mPDLIM LIM domain - NMR<br />
 +
**[[4ydp]] - hPDLIM PDZ domain <br />
*PDLIM4
*PDLIM4
 +
**[[4q2o]] – hPDLIM <br />
**[[2v1w]] – hPDLIM + α-actinin C terminal <br />
**[[2v1w]] – hPDLIM + α-actinin C terminal <br />
**[[2eeg]] – hPDLIM PDZ domain - NMR<br />
**[[2eeg]] – hPDLIM PDZ domain - NMR<br />
Line 38: Line 51:
**[[2q3g]] – hPDLIM PDZ domain + β-tropomysin C terminal <br />
**[[2q3g]] – hPDLIM PDZ domain + β-tropomysin C terminal <br />
 +
**[[7rm8]] – hPDLIM PDZ domain + SNX17 peptide - NMR <br />
 +
 +
*PDLIM
 +
 +
**[[1rgw]] – hPDLIM PDZ domain - NMR<br />
}}
}}
 +
== References ==
 +
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry 2pa1)

Drag the structure with the mouse to rotate

3D structures of PDZ and LIM domain protein

Updated on 21-August-2023

References

  1. ↑ te Velthuis AJ, Bagowski CP. PDZ and LIM domain-encoding genes: molecular interactions and their role in development. ScientificWorldJournal. 2007 Sep 1;7:1470-92. PMID:17767364 doi:10.1100/tsw.2007.232

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/PDZ_and_LIM_domain_protein"
Personal tools