Nucleoside triphosphatase
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | < | + | |
| + | <StructureSection load='4a5a' size='350' side='right' caption='NTPase 2 tetramer complex with AMPPNP and Mg++ ion (green) (PDB entry [[4a5a]])' scene=''> | ||
== Function == | == Function == | ||
| Line 12: | Line 13: | ||
''Toxoplasma gondii'' <snapshot name='84/844927/Cv1/3'>NTPase 2 is dimer of dimers</snapshot> (PDB code [[4a5a]]). The 3D structure of the complex between NTPase 2 and the ATP analog AMPPNP shows the NTPase structure composed of two domains. Domain I contains the N-terminal and C-terminal and domain II the core residues. The structure contains 7 Cys-Cys bonds one of which located between domain I and II and reaching the diametrically positioned monomer was found by mutational analysis to be responsible for activation. The ATP analog - AMPPNP - is located in a cleft and forms interactions with domain I and domain II<ref>PMID:22130673</ref>. | ''Toxoplasma gondii'' <snapshot name='84/844927/Cv1/3'>NTPase 2 is dimer of dimers</snapshot> (PDB code [[4a5a]]). The 3D structure of the complex between NTPase 2 and the ATP analog AMPPNP shows the NTPase structure composed of two domains. Domain I contains the N-terminal and C-terminal and domain II the core residues. The structure contains 7 Cys-Cys bonds one of which located between domain I and II and reaching the diametrically positioned monomer was found by mutational analysis to be responsible for activation. The ATP analog - AMPPNP - is located in a cleft and forms interactions with domain I and domain II<ref>PMID:22130673</ref>. | ||
*<snapshot name='84/844927/Cv1/5'>Test1</snapshot> | *<snapshot name='84/844927/Cv1/5'>Test1</snapshot> | ||
| - | *<snapshot name='84/844927/Cv1/6'>Test2</snapshot> | + | *<snapshot name='84/844927/Cv1/6'>Test2</snapshot> |
| + | *<snapshot name='84/844927/Cv1/8'>Test3</snapshot> | ||
</SX> | </SX> | ||
| Line 46: | Line 48: | ||
**[[3s86]] - NTPase - ''Thermotoga maritima'' <br /> | **[[3s86]] - NTPase - ''Thermotoga maritima'' <br /> | ||
**[[3agr]] - NTPase - ''Neospora caninum'' <br /> | **[[3agr]] - NTPase - ''Neospora caninum'' <br /> | ||
| + | **[[7aoh]] - NTPase I in transcribing complex - Vaccinia virus – Cryo EM <br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
