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1r0o

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==Crystal Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex==
==Crystal Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex==
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<StructureSection load='1r0o' size='340' side='right' caption='[[1r0o]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
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<StructureSection load='1r0o' size='340' side='right'caption='[[1r0o]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1r0o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R0O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1r0o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R0O FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1r0n|1r0n]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">USP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), ECR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r0o OCA], [https://pdbe.org/1r0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r0o RCSB], [https://www.ebi.ac.uk/pdbsum/1r0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r0o ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r0o OCA], [http://pdbe.org/1r0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r0o RCSB], [http://www.ebi.ac.uk/pdbsum/1r0o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r0o ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ECR_DROME ECR_DROME]] Receptor for ecdysone. Binds to ecdysone response elements (ECRES) following ecdysone-binding, and recruitment of a complex containing the histone methyltransferase trr, leads to activate transcription of target genes.<ref>PMID:1913820</ref> [[http://www.uniprot.org/uniprot/USP_DROME USP_DROME]] Receptor for ecdysone. May be an important modulator of insect metamorphosis. Plays an important part in embryonic and post-embryonic development. Binds to ecdysone response elements (ECRES) such as in the promoter region of s15 chorion gene.
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[https://www.uniprot.org/uniprot/USP_DROME USP_DROME] Receptor for ecdysone. May be an important modulator of insect metamorphosis. Plays an important part in embryonic and post-embryonic development. Binds to ecdysone response elements (ECRES) such as in the promoter region of s15 chorion gene.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drome]]
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[[Category: Drosophila melanogaster]]
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[[Category: Devarakonda, S]]
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[[Category: Large Structures]]
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[[Category: Harp, J M]]
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[[Category: Devarakonda S]]
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[[Category: Kim, Y]]
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[[Category: Harp JM]]
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[[Category: Ozyhar, A]]
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[[Category: Kim Y]]
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[[Category: Rastinejad, F]]
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[[Category: Ozyhar A]]
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[[Category: Dna binding domain]]
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[[Category: Rastinejad F]]
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[[Category: Ecdsyone receptor]]
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[[Category: Nuclear receptor]]
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[[Category: Transcription-dna complex]]
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[[Category: Ultraspiracle]]
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Current revision

Crystal Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex

PDB ID 1r0o

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