1r2h

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==Human Bcl-XL containing an Ala to Leu mutation at position 142==
==Human Bcl-XL containing an Ala to Leu mutation at position 142==
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<StructureSection load='1r2h' size='340' side='right' caption='[[1r2h]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='1r2h' size='340' side='right'caption='[[1r2h]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1r2h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R2H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1r2h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R2H FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1maz|1maz]], [[1r2d|1r2d]], [[1r2e|1r2e]], [[1r2g|1r2g]], [[1r2i|1r2i]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL-XL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r2h OCA], [https://pdbe.org/1r2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r2h RCSB], [https://www.ebi.ac.uk/pdbsum/1r2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r2h ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r2h OCA], [http://pdbe.org/1r2h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r2h RCSB], [http://www.ebi.ac.uk/pdbsum/1r2h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r2h ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
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[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r2/1r2h_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r2/1r2h_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 1r2h" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1r2h" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Giedt, C D]]
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[[Category: Large Structures]]
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[[Category: Hockenbery, D M]]
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[[Category: Giedt CD]]
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[[Category: Kim, K M]]
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[[Category: Hockenbery DM]]
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[[Category: Manion, M K]]
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[[Category: Kim KM]]
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[[Category: Neill, J W.O]]
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[[Category: Manion MK]]
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[[Category: Zhang, K Y]]
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[[Category: O'Neill JW]]
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[[Category: Alpha-helical]]
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[[Category: Zhang KY]]
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[[Category: Apoptosis]]
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[[Category: Monomeric]]
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[[Category: Mutation]]
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Current revision

Human Bcl-XL containing an Ala to Leu mutation at position 142

PDB ID 1r2h

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