1rj2

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{{Seed}}
 
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[[Image:1rj2.png|left|200px]]
 
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==Crystal structure of the DH/PH fragment of Dbs without bound GTPase==
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The line below this paragraph, containing "STRUCTURE_1rj2", creates the "Structure Box" on the page.
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<StructureSection load='1rj2' size='340' side='right'caption='[[1rj2]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rj2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RJ2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rj2 OCA], [https://pdbe.org/1rj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rj2 RCSB], [https://www.ebi.ac.uk/pdbsum/1rj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rj2 ProSAT]</span></td></tr>
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{{STRUCTURE_1rj2| PDB=1rj2 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCF2L_MOUSE MCF2L_MOUSE] Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rj/1rj2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rj2 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dbl proteins are guanine nucleotide exchange factors for Rho GTPases, containing adjacent Dbl homology (DH) and pleckstrin homology (PH) domains. This domain architecture is virtually invariant and typically required for full exchange potential. Several structures of DH/PH fragments bound to GTPases implicate the PH domain in nucleotide exchange. To more fully understand the functional linkage between DH and PH domains, we have determined the crystal structure of the DH/PH fragment of Dbs without bound GTPase. This structure is generally similar to previously determined structures of Dbs bound to GTPases albeit with greater apparent mobility between the DH and PH domains. These comparisons suggest that the DH and PH domains of Dbs are spatially primed for binding GTPases and small alterations in intradomain conformations that may be elicited by subtle biological responses, such as altered phosphoinositide levels, are sufficient to enhance exchange by facilitating interactions between the PH domain and GTPases.
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===Crystal structure of the DH/PH fragment of Dbs without bound GTPase===
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Crystal structure of the DH/PH fragment of Dbs without bound GTPase.,Worthylake DK, Rossman KL, Sondek J Structure. 2004 Jun;12(6):1078-86. PMID:15274927<ref>PMID:15274927</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15274927}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1rj2" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15274927 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15274927}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1RJ2 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJ2 OCA].
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==Reference==
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<ref group="xtra">PMID:15274927</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Rossman, K L.]]
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[[Category: Rossman KL]]
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[[Category: Sondek, J.]]
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[[Category: Sondek J]]
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[[Category: Worthylake, D K.]]
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[[Category: Worthylake DK]]
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[[Category: Dbl homology]]
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[[Category: Guanine nucleotide exchange factor]]
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[[Category: Pleckstrin homology]]
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[[Category: Rho gtpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:49:04 2009''
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Current revision

Crystal structure of the DH/PH fragment of Dbs without bound GTPase

PDB ID 1rj2

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