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1rm8

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Current revision (06:06, 23 August 2023) (edit) (undo)
 
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<StructureSection load='1rm8' size='340' side='right'caption='[[1rm8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='1rm8' size='340' side='right'caption='[[1rm8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1rm8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RM8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1rm8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RM8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAT:4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE'>BAT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bqq|1bqq]], [[1jk3|1jk3]], [[1mmb|1mmb]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAT:4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE'>BAT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rm8 OCA], [https://pdbe.org/1rm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rm8 RCSB], [https://www.ebi.ac.uk/pdbsum/1rm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rm8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rm8 OCA], [https://pdbe.org/1rm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rm8 RCSB], [https://www.ebi.ac.uk/pdbsum/1rm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rm8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MMP16_HUMAN MMP16_HUMAN]] Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
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[https://www.uniprot.org/uniprot/MMP16_HUMAN MMP16_HUMAN] Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bode, W]]
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[[Category: Bode W]]
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[[Category: Braun, M]]
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[[Category: Braun M]]
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[[Category: Foidart, J M]]
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[[Category: Foidart J-M]]
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[[Category: Frankenne, F]]
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[[Category: Frankenne F]]
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[[Category: Lang, R]]
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[[Category: Lang R]]
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[[Category: Maskos, K]]
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[[Category: Maskos K]]
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[[Category: Noel, A]]
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[[Category: Noel A]]
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[[Category: Sounni, N E]]
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[[Category: Sounni NE]]
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[[Category: Batimastat]]
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[[Category: Hydrolase]]
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[[Category: Hydroxamate inhibitor]]
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[[Category: Membrane type - matrix metalloproteinase]]
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[[Category: Mmp-16]]
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[[Category: Mt-mmp]]
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[[Category: Mt3-mmp]]
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[[Category: Protease]]
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Current revision

Crystal structure of the catalytic domain of MMP-16/MT3-MMP: Characterization of MT-MMP specific features

PDB ID 1rm8

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