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1rz5

From Proteopedia

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[[Image:1rz5.jpg|left|200px]]
 
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==Di-haem Cytochrome c Peroxidase, Form OUT==
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The line below this paragraph, containing "STRUCTURE_1rz5", creates the "Structure Box" on the page.
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<StructureSection load='1rz5' size='340' side='right'caption='[[1rz5]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Marinobacter_nauticus Marinobacter nauticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RZ5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
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{{STRUCTURE_1rz5| PDB=1rz5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz5 OCA], [https://pdbe.org/1rz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rz5 RCSB], [https://www.ebi.ac.uk/pdbsum/1rz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rz5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P83787_MARNT P83787_MARNT]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rz/1rz5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rz5 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cytochrome c peroxidase (CCP) catalyses the reduction of H(2)O(2) to H(2)O, an important step in the cellular detoxification process. The crystal structure of the di-heme CCP from Pseudomonas nautica 617 was obtained in two different conformations in a redox state with the electron transfer heme reduced. Form IN, obtained at pH 4.0, does not contain Ca(2+) and was refined at 2.2 A resolution. This inactive form presents a closed conformation where the peroxidatic heme adopts a six-ligand coordination, hindering the peroxidatic reaction from taking place. Form OUT is Ca(2+) dependent and was crystallized at pH 5.3 and refined at 2.4 A resolution. This active form shows an open conformation, with release of the distal histidine (His71) ligand, providing peroxide access to the active site. This is the first time that the active and inactive states are reported for a di-heme peroxidase.
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'''Di-haem Cytochrome c Peroxidase, Form OUT'''
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Structural basis for the mechanism of Ca(2+) activation of the di-heme cytochrome c peroxidase from Pseudomonas nautica 617.,Dias JM, Alves T, Bonifacio C, Pereira AS, Trincao J, Bourgeois D, Moura I, Romao MJ Structure. 2004 Jun;12(6):961-73. PMID:15274917<ref>PMID:15274917</ref>
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==Overview==
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Cytochrome c peroxidase (CCP) catalyses the reduction of H(2)O(2) to H(2)O, an important step in the cellular detoxification process. The crystal structure of the di-heme CCP from Pseudomonas nautica 617 was obtained in two different conformations in a redox state with the electron transfer heme reduced. Form IN, obtained at pH 4.0, does not contain Ca(2+) and was refined at 2.2 A resolution. This inactive form presents a closed conformation where the peroxidatic heme adopts a six-ligand coordination, hindering the peroxidatic reaction from taking place. Form OUT is Ca(2+) dependent and was crystallized at pH 5.3 and refined at 2.4 A resolution. This active form shows an open conformation, with release of the distal histidine (His71) ligand, providing peroxide access to the active site. This is the first time that the active and inactive states are reported for a di-heme peroxidase.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1RZ5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Marinobacter_hydrocarbonoclasticus Marinobacter hydrocarbonoclasticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ5 OCA].
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</div>
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<div class="pdbe-citations 1rz5" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Structural basis for the mechanism of Ca(2+) activation of the di-heme cytochrome c peroxidase from Pseudomonas nautica 617., Dias JM, Alves T, Bonifacio C, Pereira AS, Trincao J, Bourgeois D, Moura I, Romao MJ, Structure. 2004 Jun;12(6):961-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15274917 15274917]
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*[[Cytochrome c peroxidase 3D structures|Cytochrome c peroxidase 3D structures]]
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[[Category: Cytochrome-c peroxidase]]
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== References ==
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[[Category: Marinobacter hydrocarbonoclasticus]]
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<references/>
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[[Category: Single protein]]
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__TOC__
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[[Category: Alves, T.]]
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</StructureSection>
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[[Category: Bonifacio, C.]]
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[[Category: Large Structures]]
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[[Category: Bourgeois, D.]]
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[[Category: Marinobacter nauticus]]
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[[Category: Dias, J M.]]
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[[Category: Alves T]]
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[[Category: Moura, I.]]
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[[Category: Bonifacio C]]
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[[Category: Pereira, A S.]]
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[[Category: Bourgeois D]]
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[[Category: Romao, M J.]]
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[[Category: Dias JM]]
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[[Category: Electron transport]]
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[[Category: Moura I]]
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[[Category: Haem]]
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[[Category: Pereira AS]]
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[[Category: Oxidoreductase]]
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[[Category: Romao MJ]]
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[[Category: Peroxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:05:31 2008''
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Current revision

Di-haem Cytochrome c Peroxidase, Form OUT

PDB ID 1rz5

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