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1s1g

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==Crystal Structure of Kv4.3 T1 Domain==
==Crystal Structure of Kv4.3 T1 Domain==
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<StructureSection load='1s1g' size='340' side='right' caption='[[1s1g]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='1s1g' size='340' side='right'caption='[[1s1g]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1s1g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S1G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1s1g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S1G FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s1e|1s1e]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KCND3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1g OCA], [https://pdbe.org/1s1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s1g RCSB], [https://www.ebi.ac.uk/pdbsum/1s1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s1g ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1g OCA], [http://pdbe.org/1s1g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s1g RCSB], [http://www.ebi.ac.uk/pdbsum/1s1g PDBsum]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/KCND3_HUMAN KCND3_HUMAN]] Note=KCND3 rare variants may confer risk for lethal ventricular arrhytmias and be associated with autopsy-negative sudden unexplained death syndrome (SUDS).<ref>PMID:22457051</ref>
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[https://www.uniprot.org/uniprot/KCND3_HUMAN KCND3_HUMAN] Note=KCND3 rare variants may confer risk for lethal ventricular arrhytmias and be associated with autopsy-negative sudden unexplained death syndrome (SUDS).<ref>PMID:22457051</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KCND3_HUMAN KCND3_HUMAN]] Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.<ref>PMID:9843794</ref> <ref>PMID:10200233</ref>
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[https://www.uniprot.org/uniprot/KCND3_HUMAN KCND3_HUMAN] Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.<ref>PMID:9843794</ref> <ref>PMID:10200233</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s1/1s1g_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s1/1s1g_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s1g ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
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*[[Potassium Channel|Potassium Channel]]
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Bowlby, M R]]
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[[Category: Large Structures]]
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[[Category: Carroll, K C]]
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[[Category: Bowlby MR]]
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[[Category: Chanda, P]]
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[[Category: Carroll KC]]
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[[Category: Edris, W]]
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[[Category: Chanda P]]
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[[Category: Jow, F]]
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[[Category: Edris W]]
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[[Category: Katz, A H]]
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[[Category: Jow F]]
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[[Category: Kopsco, D C]]
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[[Category: Katz AH]]
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[[Category: Lin, L]]
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[[Category: Kopsco DC]]
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[[Category: Lu, Q]]
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[[Category: Lin L]]
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[[Category: Malakian, K]]
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[[Category: Lu Q]]
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[[Category: Megules, J]]
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[[Category: Malakian K]]
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[[Category: Mosyak, L]]
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[[Category: Megules J]]
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[[Category: Olland, S]]
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[[Category: Mosyak L]]
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[[Category: Rhodes, K J]]
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[[Category: Olland S]]
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[[Category: Scannevin, R H]]
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[[Category: Rhodes KJ]]
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[[Category: Somers, W]]
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[[Category: Scannevin RH]]
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[[Category: Stahl, M]]
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[[Category: Somers W]]
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[[Category: Taylor, M]]
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[[Category: Stahl M]]
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[[Category: Wang, K W]]
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[[Category: Taylor M]]
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[[Category: Xu, W X]]
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[[Category: Wang KW]]
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[[Category: Xu, Z B]]
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[[Category: Xu WX]]
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[[Category: K+ channel]]
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[[Category: Xu ZB]]
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[[Category: T1 domain]]
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[[Category: Tetramerization domain]]
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[[Category: Transport protein]]
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Current revision

Crystal Structure of Kv4.3 T1 Domain

PDB ID 1s1g

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