This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1s5i

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:13, 23 August 2023) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1s5i.jpg|left|200px]]
 
-
<!--
+
==Fab (LNKB-2) of monoclonal antibody to Human Interleukin-2, crystal structure==
-
The line below this paragraph, containing "STRUCTURE_1s5i", creates the "Structure Box" on the page.
+
<StructureSection load='1s5i' size='340' side='right'caption='[[1s5i]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1s5i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S5I FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s5i OCA], [https://pdbe.org/1s5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s5i RCSB], [https://www.ebi.ac.uk/pdbsum/1s5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s5i ProSAT]</span></td></tr>
-
{{STRUCTURE_1s5i| PDB=1s5i | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IGH1M_MOUSE IGH1M_MOUSE]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s5/1s5i_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s5i ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 in a new crystal form (space group P2(1)2(1)2(1); unit cell parameters: a = 42.82, b = 90.68, and c = 139.82 A) was determined by the X-ray molecular replacement method at the resolution of 2.7 A. The protein folding and the stereochemistry of its antigen-binding site were comparatively analyzed. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 5; see also http: // www.maik.ru.
-
'''Fab (LNKB-2) of monoclonal antibody to Human Interleukin-2, crystal structure'''
+
[A new crystal form of the Fab fragment of a monoclonal antibody to human interleukin-2: the three-dimensional structure at 2.7 A resolution].,Pletnev VZ, Goriacheva EA, Tsygannik IN, Nesmeianov VA, Pletnev SV, Pangborn W, Daux W Bioorg Khim. 2004 Sep-Oct;30(5):466-9. PMID:15562966<ref>PMID:15562966</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
==About this Structure==
+
</div>
-
1S5I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5I OCA].
+
<div class="pdbe-citations 1s5i" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Single protein]]
+
[[Category: Duax W]]
-
[[Category: Duax, W.]]
+
[[Category: Goryacheva EA]]
-
[[Category: Goryacheva, E A.]]
+
[[Category: Nesmeyanov VA]]
-
[[Category: Nesmeyanov, V A.]]
+
[[Category: Pangborn W]]
-
[[Category: Pangborn, W.]]
+
[[Category: Pletnev SV]]
-
[[Category: Pletnev, S V.]]
+
[[Category: Pletnev VZ]]
-
[[Category: Pletnev, V Z.]]
+
[[Category: Tsygannik IN]]
-
[[Category: Tsygannik, I N.]]
+
-
[[Category: Antigen-binding fragment]]
+
-
[[Category: Crystal structure]]
+
-
[[Category: Interleukin-2]]
+
-
[[Category: Monoclonal antibody]]
+
-
[[Category: X-ray analysis]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:19:34 2008''
+

Current revision

Fab (LNKB-2) of monoclonal antibody to Human Interleukin-2, crystal structure

PDB ID 1s5i

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1s5i"
Personal tools