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1shm

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==Convergent solutions to VHH domain stabilization from natural and in vitro evolution==
==Convergent solutions to VHH domain stabilization from natural and in vitro evolution==
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<StructureSection load='1shm' size='340' side='right' caption='[[1shm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='1shm' size='340' side='right'caption='[[1shm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1shm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SHM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1shm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SHM FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hcv|1hcv]], [[1mel|1mel]], [[1f2x|1f2x]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1shm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1shm RCSB], [http://www.ebi.ac.uk/pdbsum/1shm PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1shm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shm OCA], [https://pdbe.org/1shm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1shm RCSB], [https://www.ebi.ac.uk/pdbsum/1shm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1shm ProSAT]</span></td></tr>
</table>
</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
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Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sh/1shm_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sh/1shm_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1shm ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1shm" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Antibody|Antibody]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Lama glama]]
[[Category: Lama glama]]
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[[Category: Bond, C J]]
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[[Category: Large Structures]]
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[[Category: Marsters, J C]]
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[[Category: Bond CJ]]
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[[Category: Sidhu, S S]]
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[[Category: Marsters JC]]
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[[Category: Wiesmann, C]]
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[[Category: Sidhu SS]]
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[[Category: Heavy chain variable domain]]
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[[Category: Wiesmann C]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin]]
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[[Category: Vhh domain]]
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Current revision

Convergent solutions to VHH domain stabilization from natural and in vitro evolution

PDB ID 1shm

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