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1t2a

From Proteopedia

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[[Image:1t2a.gif|left|200px]]
 
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{{Structure
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==Crystal structure of human GDP-D-mannose 4,6-dehydratase==
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|PDB= 1t2a |SIZE=350|CAPTION= <scene name='initialview01'>1t2a</scene>, resolution 1.84&Aring;
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<StructureSection load='1t2a' size='340' side='right'caption='[[1t2a]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>
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<table><tr><td colspan='2'>[[1t2a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T2A FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/GDP-mannose_4,6-dehydratase GDP-mannose 4,6-dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.47 4.2.1.47] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
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|GENE= GMDS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2a OCA], [https://pdbe.org/1t2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t2a RCSB], [https://www.ebi.ac.uk/pdbsum/1t2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t2a ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2a OCA], [http://www.ebi.ac.uk/pdbsum/1t2a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t2a RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/GMDS_HUMAN GMDS_HUMAN] Conversion of GDP-D-mannose to GDP-4-keto-6-D-deoxymannose.
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== Evolutionary Conservation ==
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'''Crystal structure of human GDP-D-mannose 4,6-dehydratase'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t2/1t2a_consurf.spt"</scriptWhenChecked>
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1T2A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2A OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: GDP-mannose 4,6-dehydratase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t2a ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Houston, S.]]
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[[Category: Houston S]]
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[[Category: Loppnau, P.]]
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[[Category: Loppnau P]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann U]]
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[[Category: Sharma, S.]]
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[[Category: Sharma S]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Vedadi, M.]]
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[[Category: Vedadi M]]
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[[Category: Walker, J R.]]
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[[Category: Walker JR]]
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[[Category: Wasney, G.]]
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[[Category: Wasney G]]
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[[Category: rossman-fold]]
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[[Category: sdr]]
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[[Category: short-chain dehydrogenase/reductase]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:50:13 2008''
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Current revision

Crystal structure of human GDP-D-mannose 4,6-dehydratase

PDB ID 1t2a

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