This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1tgm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:29, 23 August 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1tgm.png|left|200px]]
 
-
<!--
+
==Crystal structure of a complex formed between group II phospholipase A2 and aspirin at 1.86 A resolution==
-
The line below this paragraph, containing "STRUCTURE_1tgm", creates the "Structure Box" on the page.
+
<StructureSection load='1tgm' size='340' side='right'caption='[[1tgm]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1tgm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russelii_russelii Daboia russelii russelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TGM FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AIN:2-(ACETYLOXY)BENZOIC+ACID'>AIN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1tgm| PDB=1tgm | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tgm OCA], [https://pdbe.org/1tgm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tgm RCSB], [https://www.ebi.ac.uk/pdbsum/1tgm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tgm ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tg/1tgm_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tgm ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of a complex formed between group II phospholipase A2 and aspirin at 1.86 A resolution===
+
==See Also==
-
 
+
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
1TGM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_russellii Daboia russellii russellii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGM OCA].
+
__TOC__
-
[[Category: Daboia russellii russellii]]
+
</StructureSection>
-
[[Category: Bhushan, A.]]
+
[[Category: Daboia russelii russelii]]
-
[[Category: Jabeen, T.]]
+
[[Category: Large Structures]]
-
[[Category: Sharma, S.]]
+
[[Category: Bhushan A]]
-
[[Category: Singh, N.]]
+
[[Category: Jabeen T]]
-
[[Category: Singh, T P.]]
+
[[Category: Sharma S]]
-
[[Category: Complex]]
+
[[Category: Singh N]]
-
[[Category: Enzyme]]
+
[[Category: Singh TP]]
-
[[Category: Phospholipase a2]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:00:07 2009''
+

Current revision

Crystal structure of a complex formed between group II phospholipase A2 and aspirin at 1.86 A resolution

PDB ID 1tgm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tgm"
Personal tools