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1tp8

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==CRYSTAL STRUCTURE OF A GALACTOSE SPECIFIC LECTIN FROM ARTOCARPUS HIRSUTA IN COMPLEX WITH METHYL-a-D-GALACTOSE==
==CRYSTAL STRUCTURE OF A GALACTOSE SPECIFIC LECTIN FROM ARTOCARPUS HIRSUTA IN COMPLEX WITH METHYL-a-D-GALACTOSE==
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<StructureSection load='1tp8' size='340' side='right' caption='[[1tp8]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='1tp8' size='340' side='right'caption='[[1tp8]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1tp8]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Artocarpus_hirsutus Artocarpus hirsutus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TP8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TP8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1tp8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Artocarpus_hirsutus Artocarpus hirsutus] and [https://en.wikipedia.org/wiki/Artocarpus_integer Artocarpus integer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TP8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMG:ALPHA-METHYL-D-GALACTOSIDE'>AMG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1toq|1toq]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMG:ALPHA-METHYL-D-GALACTOSIDE'>AMG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tp8 OCA], [http://pdbe.org/1tp8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tp8 RCSB], [http://www.ebi.ac.uk/pdbsum/1tp8 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tp8 OCA], [https://pdbe.org/1tp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tp8 RCSB], [https://www.ebi.ac.uk/pdbsum/1tp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tp8 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LECA_ARTIN LECA_ARTIN] D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tp/1tp8_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tp/1tp8_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 1tp8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1tp8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Agglutinin 3D structures|Agglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Artocarpus hirsutus]]
[[Category: Artocarpus hirsutus]]
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[[Category: Gaikwad, S M]]
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[[Category: Artocarpus integer]]
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[[Category: Katre, U V]]
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[[Category: Large Structures]]
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[[Category: Khan, M I]]
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[[Category: Gaikwad SM]]
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[[Category: Rao, K N]]
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[[Category: Katre UV]]
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[[Category: Suresh, C G]]
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[[Category: Khan MI]]
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[[Category: Prism i fold]]
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[[Category: Rao KN]]
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[[Category: Artocarpus hirsuta]]
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[[Category: Suresh CG]]
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[[Category: Carbohydrate specificity]]
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[[Category: Jacalin family]]
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[[Category: Methyl--d-galactose]]
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[[Category: Moraceae plant lectin]]
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[[Category: Post-translational modification]]
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[[Category: Sugar binding protein]]
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[[Category: Three-dimensional structure]]
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Current revision

CRYSTAL STRUCTURE OF A GALACTOSE SPECIFIC LECTIN FROM ARTOCARPUS HIRSUTA IN COMPLEX WITH METHYL-a-D-GALACTOSE

PDB ID 1tp8

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