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1tw9

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[[Image:1tw9.gif|left|200px]]
 
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{{Structure
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==Glutathione Transferase-2, apo form, from the nematode Heligmosomoides polygyrus==
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|PDB= 1tw9 |SIZE=350|CAPTION= <scene name='initialview01'>1tw9</scene>, resolution 1.71&Aring;
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<StructureSection load='1tw9' size='340' side='right'caption='[[1tw9]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1tw9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Heligmosomoides_polygyrus Heligmosomoides polygyrus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TW9 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tw9 OCA], [https://pdbe.org/1tw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tw9 RCSB], [https://www.ebi.ac.uk/pdbsum/1tw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tw9 ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9NJQ6_HELPZ Q9NJQ6_HELPZ]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tw/1tw9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tw9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of GST Nu2-2 (HpolGSTN2-2) from the model hookworm nematode Heligmosomoides polygyrus has been solved by the molecular replacement method and refined to a resolution of 1.71 A, providing the first structural data from a class of nematode-specific GSTs. By structural alignment with two Sigma class GSTs, glutathione could be rationally docked into the G-site of the enzyme. By comparing with all mammalian GST classes, a novel, long, and deep cleft was identified at the H-site, providing a potential site for ligand binding. This new GST class may support the establishment of infection parasitic nematodes by passively neutralizing chemical toxins derived from host environment. The structure serves as a starting point for structure-based drug/inhibitor design that would aim to selectively disrupt nematode chemical defenses.
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'''Glutathione Transferase-2, apo form, from the nematode Heligmosomoides polygyrus'''
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Crystal structure of a new class of glutathione transferase from the model human hookworm nematode Heligmosomoides polygyrus.,Schuller DJ, Liu Q, Kriksunov IA, Campbell AM, Barrett J, Brophy PM, Hao Q Proteins. 2005 Dec 1;61(4):1024-31. PMID:16189827<ref>PMID:16189827</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1tw9" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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1TW9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Heligmosomoides_polygyrus Heligmosomoides polygyrus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TW9 OCA].
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Heligmosomoides polygyrus]]
[[Category: Heligmosomoides polygyrus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Barrett, J.]]
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[[Category: Barrett J]]
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[[Category: Brophy, P M.]]
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[[Category: Brophy PM]]
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[[Category: Campbell, A M.]]
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[[Category: Campbell AM]]
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[[Category: Hao, Q.]]
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[[Category: Hao Q]]
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[[Category: Kriksunov, I A.]]
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[[Category: Kriksunov IA]]
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[[Category: Liu, Q.]]
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[[Category: Liu Q]]
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[[Category: Schuller, D J.]]
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[[Category: Schuller DJ]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:24:05 2008''
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Current revision

Glutathione Transferase-2, apo form, from the nematode Heligmosomoides polygyrus

PDB ID 1tw9

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