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1vxo

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METHYLPHOSPHONYLATED ACETYLCHOLINESTERASE (AGED) OBTAINED BY REACTION WITH O-ETHYL-S-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL] METHYLPHOSPHONOTHIOATE (VX)

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Retrieved from "http://52.214.119.220/wiki/index.php/1vxo"

Categories: Large Structures | Tetronarce californica | Millard CB | Silman I | Sussman JL

@@ Line 1: / Line 1: @@
-[[Image:1vxo.gif|left|200px]]<br />
-<applet load="1vxo" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1vxo, resolution 2.400&Aring;" />
-'''METHYLPHOSPHONYLATED ACETYLCHOLINESTERASE (AGED) OBTAINED BY REACTION WITH O-ETHYL-S-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL] METHYLPHOSPHONOTHIOATE (VX)'''<br />
-==About this Structure==
+==METHYLPHOSPHONYLATED ACETYLCHOLINESTERASE (AGED) OBTAINED BY REACTION WITH O-ETHYL-S-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL] METHYLPHOSPHONOTHIOATE (VX)==
-VXO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica] with NAG, NDG and VXA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VXO OCA].
+<StructureSection load='1vxo' size='340' side='right'caption='[[1vxo]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-[[Category: Acetylcholinesterase]]
+== Structural highlights ==
-[[Category: Single protein]]
+<table><tr><td colspan='2'>[[1vxo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VXO FirstGlance]. <br>
-[[Category: Torpedo californica]]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-[[Category: Millard, C.B.]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=VXA:METHYLPHOSPHONIC+ACID+ESTER+GROUP'>VXA</scene></td></tr>
-[[Category: Silman, I.]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vxo OCA], [https://pdbe.org/1vxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vxo RCSB], [https://www.ebi.ac.uk/pdbsum/1vxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vxo ProSAT]</span></td></tr>
-[[Category: Sussman, J.L.]]
+</table>
-[[Category: NAG]]
+== Function ==
-[[Category: NDG]]
+[https://www.uniprot.org/uniprot/ACES_TETCF ACES_TETCF] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
-[[Category: VXA]]
+== Evolutionary Conservation ==
-[[Category: chemical-warfare]]
+[[Image:Consurf_key_small.gif|200px|right]]
-[[Category: cholinesterase]]
+Check<jmol>
-[[Category: organophosphate]]
+  <jmolCheckbox>
-[[Category: serine hydrolase]]
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vx/1vxo_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vxo ConSurf].
+<div style="clear:both"></div>
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov  8 12:44:56 2007''
+==See Also==
+*[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Tetronarce californica]]
+[[Category: Millard CB]]
+[[Category: Silman I]]
+[[Category: Sussman JL]]

1vxo

From Proteopedia

Current revision

METHYLPHOSPHONYLATED ACETYLCHOLINESTERASE (AGED) OBTAINED BY REACTION WITH O-ETHYL-S-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL] METHYLPHOSPHONOTHIOATE (VX)

Structural highlights

Function

Evolutionary Conservation

See Also

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