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1xbo
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==PTP1B complexed with Isoxazole Carboxylic Acid== | ==PTP1B complexed with Isoxazole Carboxylic Acid== | ||
| - | <StructureSection load='1xbo' size='340' side='right' caption='[[1xbo]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='1xbo' size='340' side='right'caption='[[1xbo]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1xbo]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1xbo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XBO FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IX1:5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC+ACID'>IX1</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xbo OCA], [https://pdbe.org/1xbo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xbo RCSB], [https://www.ebi.ac.uk/pdbsum/1xbo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xbo ProSAT]</span></td></tr> |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/1xbo_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/1xbo_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 1xbo" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1xbo" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Abad-Zapatero | + | [[Category: Abad-Zapatero C]] |
| - | [[Category: Ballaron | + | [[Category: Ballaron SJ]] |
| - | [[Category: Hajduk | + | [[Category: Hajduk PJ]] |
| - | [[Category: Hassach | + | [[Category: Hassach DL]] |
| - | [[Category: Hutchins | + | [[Category: Hutchins CW]] |
| - | [[Category: Jirousek | + | [[Category: Jirousek MR]] |
| - | [[Category: Kaszubska | + | [[Category: Kaszubska W]] |
| - | [[Category: Liu | + | [[Category: Liu G]] |
| - | [[Category: Lubben | + | [[Category: Lubben TH]] |
| - | [[Category: Pei | + | [[Category: Pei Z]] |
| - | [[Category: Rondinone | + | [[Category: Rondinone CM]] |
| - | [[Category: Serby | + | [[Category: Serby M]] |
| - | [[Category: Szczepankiewicz | + | [[Category: Szczepankiewicz BG]] |
| - | [[Category: Trevillyan | + | [[Category: Trevillyan JM]] |
| - | [[Category: Xin | + | [[Category: Xin Z]] |
| - | [[Category: Zhao | + | [[Category: Zhao H]] |
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Current revision
PTP1B complexed with Isoxazole Carboxylic Acid
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Categories: Homo sapiens | Large Structures | Abad-Zapatero C | Ballaron SJ | Hajduk PJ | Hassach DL | Hutchins CW | Jirousek MR | Kaszubska W | Liu G | Lubben TH | Pei Z | Rondinone CM | Serby M | Szczepankiewicz BG | Trevillyan JM | Xin Z | Zhao H
