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1xbo

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Current revision (06:43, 23 August 2023) (edit) (undo)
 
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<StructureSection load='1xbo' size='340' side='right'caption='[[1xbo]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1xbo' size='340' side='right'caption='[[1xbo]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1xbo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XBO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XBO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1xbo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XBO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IX1:5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC+ACID'>IX1</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nl9|1nl9]], [[1nny|1nny]], [[1no6|1no6]], [[1nzz|1nzz]], [[1ony|1ony]], [[1onz|1onz]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IX1:5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC+ACID'>IX1</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPN1, PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xbo OCA], [https://pdbe.org/1xbo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xbo RCSB], [https://www.ebi.ac.uk/pdbsum/1xbo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xbo ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xbo OCA], [http://pdbe.org/1xbo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xbo RCSB], [http://www.ebi.ac.uk/pdbsum/1xbo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xbo ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
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[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Abad-Zapatero C]]
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[[Category: Abad-Zapatero, C]]
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[[Category: Ballaron SJ]]
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[[Category: Ballaron, S J]]
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[[Category: Hajduk PJ]]
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[[Category: Hajduk, P J]]
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[[Category: Hassach DL]]
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[[Category: Hassach, D L]]
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[[Category: Hutchins CW]]
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[[Category: Hutchins, C W]]
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[[Category: Jirousek MR]]
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[[Category: Jirousek, M R]]
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[[Category: Kaszubska W]]
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[[Category: Kaszubska, W]]
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[[Category: Liu G]]
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[[Category: Liu, G]]
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[[Category: Lubben TH]]
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[[Category: Lubben, T H]]
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[[Category: Pei Z]]
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[[Category: Pei, Z]]
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[[Category: Rondinone CM]]
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[[Category: Rondinone, C M]]
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[[Category: Serby M]]
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[[Category: Serby, M]]
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[[Category: Szczepankiewicz BG]]
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[[Category: Szczepankiewicz, B G]]
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[[Category: Trevillyan JM]]
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[[Category: Trevillyan, J M]]
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[[Category: Xin Z]]
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[[Category: Xin, Z]]
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[[Category: Zhao H]]
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[[Category: Zhao, H]]
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[[Category: Hydrolase]]
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[[Category: Isoxazole carboxylic acid]]
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[[Category: Protein tyrosine phosphatase 1b]]
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[[Category: Ptp1b]]
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Current revision

PTP1B complexed with Isoxazole Carboxylic Acid

PDB ID 1xbo

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