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1xhc

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[[Image:1xhc.jpg|left|200px]]
 
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{{Structure
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==NADH oxidase /nitrite reductase from Pyrococcus furiosus Pfu-1140779-001==
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|PDB= 1xhc |SIZE=350|CAPTION= <scene name='initialview01'>1xhc</scene>, resolution 2.350&Aring;
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<StructureSection load='1xhc' size='340' side='right'caption='[[1xhc]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>
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<table><tr><td colspan='2'>[[1xhc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XHC FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00070 Pyr_redox], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1251 NirB]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xhc OCA], [https://pdbe.org/1xhc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xhc RCSB], [https://www.ebi.ac.uk/pdbsum/1xhc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xhc ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xhc OCA], [http://www.ebi.ac.uk/pdbsum/1xhc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xhc RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/NROR_PYRFU NROR_PYRFU] Catalyzes the NADH-dependent reduction of rubredoxin (Rd), a small iron-containing redox protein (PubMed:10464233, PubMed:11398485, PubMed:15746356). Can also reduce other electron carriers, including 2,6-dichlorophenol indophenol, benzyl viologen and menadione, but rubredoxin is the most efficient electron acceptor (PubMed:10464233, PubMed:11398485, PubMed:15746356). Does not reduce ferredoxin (PubMed:10464233). Shows comparable activity with NADPH and NADH as electron donors, but NADPH is probably the preferred physiological electron donor (PubMed:10464233, PubMed:11398485). Is probably part of an oxygen detoxification system that protects P.furiosus during exposure to oxygen (PubMed:15746356).<ref>PMID:10464233</ref> <ref>PMID:11398485</ref> <ref>PMID:15746356</ref>
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== Evolutionary Conservation ==
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'''NADH oxidase /nitrite reductase from Pyrococcus furiosus Pfu-1140779-001'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xh/1xhc_consurf.spt"</scriptWhenChecked>
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1XHC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus_dsm_3638 Pyrococcus furiosus dsm 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XHC OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Pyrococcus furiosus dsm 3638]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Single protein]]
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</jmolCheckbox>
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[[Category: Adams, M W.W.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xhc ConSurf].
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[[Category: Brereton, P S.]]
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<div style="clear:both"></div>
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[[Category: Chen, L.]]
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== References ==
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[[Category: Horanyi, P.]]
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<references/>
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[[Category: II, F L.Poole.]]
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__TOC__
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[[Category: III, W B.Arendall.]]
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</StructureSection>
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[[Category: Izumi, M.]]
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[[Category: Large Structures]]
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[[Category: Jr., F E.Jenney.]]
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[[Category: Pyrococcus furiosus DSM 3638]]
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[[Category: Lee, D.]]
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[[Category: Adams MWW]]
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[[Category: Liu, Z J.]]
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[[Category: Arendall III WB]]
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[[Category: Richardson, D C.]]
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[[Category: Brereton PS]]
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[[Category: Richardson, J S.]]
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[[Category: Chen L]]
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[[Category: Rose, J P.]]
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[[Category: Horanyi P]]
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[[Category: SECSG, Southeast Collaboratory for Structural Genomics.]]
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[[Category: Izumi M]]
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[[Category: Shah, A.]]
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[[Category: Jenney Jr FE]]
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[[Category: Shah, C.]]
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[[Category: Lee D]]
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[[Category: Sugar, F J.]]
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[[Category: Liu Z-J]]
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[[Category: Tempel, W.]]
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[[Category: Poole II FL]]
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[[Category: Wang, B C.]]
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[[Category: Richardson DC]]
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[[Category: Weinberg, M V.]]
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[[Category: Richardson JS]]
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[[Category: hyperthermophile]]
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[[Category: Rose JP]]
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[[Category: nadh oxidase]]
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[[Category: Shah A]]
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[[Category: nitrite reductase]]
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[[Category: Shah C]]
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[[Category: protein structure initiative]]
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[[Category: Sugar FJ]]
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[[Category: psi]]
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[[Category: Tempel W]]
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[[Category: pyrococcus furiosus]]
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[[Category: Wang B-C]]
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[[Category: secsg]]
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[[Category: Weinberg MV]]
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[[Category: southeast collaboratory for structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:49:43 2008''
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Current revision

NADH oxidase /nitrite reductase from Pyrococcus furiosus Pfu-1140779-001

PDB ID 1xhc

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