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1xiw

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==Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment==
==Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment==
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<StructureSection load='1xiw' size='340' side='right' caption='[[1xiw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='1xiw' size='340' side='right'caption='[[1xiw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1xiw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XIW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XIW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1xiw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XIW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XIW FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD3E, T3E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CD3D, T3D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), UCHT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xiw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xiw OCA], [http://pdbe.org/1xiw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xiw RCSB], [http://www.ebi.ac.uk/pdbsum/1xiw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xiw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xiw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xiw OCA], [https://pdbe.org/1xiw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xiw RCSB], [https://www.ebi.ac.uk/pdbsum/1xiw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xiw ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/CD3D_HUMAN CD3D_HUMAN]] Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:[http://omim.org/entry/608971 608971]]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.<ref>PMID:14602880</ref>
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD3E_HUMAN CD3E_HUMAN]] The CD3 complex mediates signal transduction. [[http://www.uniprot.org/uniprot/CD3D_HUMAN CD3D_HUMAN]] The CD3 complex mediates signal transduction.
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[https://www.uniprot.org/uniprot/CD3E_HUMAN CD3E_HUMAN] The CD3 complex mediates signal transduction.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[CD3|CD3]]
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*[[CD3 3D structures|CD3 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Arnett, K L]]
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[[Category: Mus musculus]]
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[[Category: Harrison, S C]]
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[[Category: Arnett KL]]
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[[Category: Wiley, D C]]
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[[Category: Harrison SC]]
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[[Category: Antibody-antigen complex]]
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[[Category: Wiley DC]]
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[[Category: Cd3-delta]]
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[[Category: Cd3-epsilon]]
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[[Category: Immunoglobulin fold]]
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[[Category: Membrane protein-immune system complex]]
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[[Category: Ucht1-scfv]]
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Current revision

Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment

PDB ID 1xiw

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