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1xje

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==Structural mechanism of allosteric substrate specificity in a ribonucleotide reductase: dTTP-GDP complex==
==Structural mechanism of allosteric substrate specificity in a ribonucleotide reductase: dTTP-GDP complex==
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<StructureSection load='1xje' size='340' side='right' caption='[[1xje]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='1xje' size='340' side='right'caption='[[1xje]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1xje]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XJE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1xje]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XJE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XJE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xjf|1xjf]], [[1xjg|1xjg]], [[1xjj|1xjj]], [[1xjk|1xjk]], [[1xjm|1xjm]], [[1xjn|1xjn]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nrdj ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xje OCA], [https://pdbe.org/1xje PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xje RCSB], [https://www.ebi.ac.uk/pdbsum/1xje PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xje ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xje OCA], [http://pdbe.org/1xje PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xje RCSB], [http://www.ebi.ac.uk/pdbsum/1xje PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O33839_THEMT O33839_THEMT]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xj/1xje_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xj/1xje_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Ribonucleotide reductase|Ribonucleotide reductase]]
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*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 43589]]
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[[Category: Large Structures]]
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[[Category: Ribonucleoside-diphosphate reductase]]
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[[Category: Thermotoga maritima]]
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[[Category: Eliasson, R]]
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[[Category: Eliasson R]]
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[[Category: Jordan, A]]
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[[Category: Jordan A]]
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[[Category: Larsson, K M]]
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[[Category: Larsson K-M]]
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[[Category: Logan, D T]]
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[[Category: Logan DT]]
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[[Category: Nordlund, P]]
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[[Category: Nordlund P]]
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[[Category: Reichard, P]]
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[[Category: Reichard P]]
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[[Category: 10 alpha-beta barrel]]
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[[Category: Allosteric regulation]]
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[[Category: Oxidoreductase]]
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[[Category: Protein-nucleotide complex]]
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[[Category: Ribonucleotide reductase]]
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[[Category: Substrate specificity]]
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Current revision

Structural mechanism of allosteric substrate specificity in a ribonucleotide reductase: dTTP-GDP complex

PDB ID 1xje

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