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1xl3

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==Complex structure of Y.pestis virulence Factors YopN and TyeA==
==Complex structure of Y.pestis virulence Factors YopN and TyeA==
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<StructureSection load='1xl3' size='340' side='right' caption='[[1xl3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='1xl3' size='340' side='right'caption='[[1xl3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1xl3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XL3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1xl3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XL3 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xkp|1xkp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">yopN, lcrE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900]), tyeA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xl3 OCA], [https://pdbe.org/1xl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xl3 RCSB], [https://www.ebi.ac.uk/pdbsum/1xl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xl3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xl3 OCA], [http://pdbe.org/1xl3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xl3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xl3 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TYEA_YERPE TYEA_YERPE]] Involved in the control of Yop release (By similarity).
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[https://www.uniprot.org/uniprot/YOPN_YERPE YOPN_YERPE] Plays a major role in regulation of the low-calcium response. Seems to sense the calcium concentration and to transmit a signal to shut off yop transcription when the calcium concentration is high (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xl/1xl3_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xl/1xl3_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cherry, S]]
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[[Category: Large Structures]]
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[[Category: Jackson, M W]]
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[[Category: Yersinia pestis]]
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[[Category: Penrose, K J]]
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[[Category: Cherry S]]
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[[Category: Plano, G V]]
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[[Category: Jackson MW]]
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[[Category: Schubot, F D]]
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[[Category: Penrose KJ]]
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[[Category: Tropea, J E]]
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[[Category: Plano GV]]
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[[Category: Waugh, D S]]
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[[Category: Schubot FD]]
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[[Category: Cell invasion]]
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[[Category: Tropea JE]]
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[[Category: Tyea]]
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[[Category: Waugh DS]]
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[[Category: Type iii secretion]]
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[[Category: Yersinia pesti]]
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[[Category: Yopn]]
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Current revision

Complex structure of Y.pestis virulence Factors YopN and TyeA

PDB ID 1xl3

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