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1xtd

From Proteopedia

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(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_1xtd", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
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[[Image:1xtd.png|left|200px]]
 
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==Structural Analysis of Leishmania mexicana eukaryotic initiation factor 5a==
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The line below this paragraph, containing "STRUCTURE_1xtd", creates the "Structure Box" on the page.
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<StructureSection load='1xtd' size='340' side='right'caption='[[1xtd]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xtd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XTD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1xtd| PDB=1xtd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xtd OCA], [https://pdbe.org/1xtd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xtd RCSB], [https://www.ebi.ac.uk/pdbsum/1xtd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xtd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IF5A_LEIMU IF5A_LEIMU] mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation (By similarity). Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity).[UniProtKB:P63241][UniProtKB:Q9GU68]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xt/1xtd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xtd ConSurf].
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<div style="clear:both"></div>
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===Structural Analysis of Leishmania mexicana eukaryotic initiation factor 5a===
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==See Also==
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[1xtd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XTD OCA].
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[[Category: Large Structures]]
[[Category: Leishmania mexicana]]
[[Category: Leishmania mexicana]]
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[[Category: Bosch, J.]]
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[[Category: Bosch J]]
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[[Category: Hol, W G.J.]]
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[[Category: Hol WGJ]]
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[[Category: SGPP, Structural Genomics of Pathogenic Protozoa Consortium.]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Sgpp]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics of pathogenic protozoa consortium]]
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[[Category: Translation]]
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Current revision

Structural Analysis of Leishmania mexicana eukaryotic initiation factor 5a

PDB ID 1xtd

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