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1yc0
From Proteopedia
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==short form HGFA with first Kunitz domain from HAI-1== | ==short form HGFA with first Kunitz domain from HAI-1== | ||
| - | <StructureSection load='1yc0' size='340' side='right' caption='[[1yc0]], [[Resolution|resolution]] 2.60Å' scene=''> | + | <StructureSection load='1yc0' size='340' side='right'caption='[[1yc0]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1yc0]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1yc0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YC0 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yc0 OCA], [https://pdbe.org/1yc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yc0 RCSB], [https://www.ebi.ac.uk/pdbsum/1yc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yc0 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/HGFA_HUMAN HGFA_HUMAN] Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yc/1yc0_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yc/1yc0_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yc0 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 1yc0" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Hepatocyte growth factor activator|Hepatocyte growth factor activator]] | ||
| + | *[[Hepatocyte growth factor activator inhibitor|Hepatocyte growth factor activator inhibitor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Corpuz | + | [[Category: Large Structures]] |
| - | [[Category: Eigenbrot | + | [[Category: Corpuz RT]] |
| - | [[Category: Fan | + | [[Category: Eigenbrot C]] |
| - | [[Category: Kirchhofer | + | [[Category: Fan B]] |
| - | [[Category: Lazarus | + | [[Category: Kirchhofer D]] |
| - | [[Category: Santell | + | [[Category: Lazarus RA]] |
| - | [[Category: Shia | + | [[Category: Santell L]] |
| - | [[Category: Stamos | + | [[Category: Shia S]] |
| - | [[Category: Wu | + | [[Category: Stamos J]] |
| - | + | [[Category: Wu J]] | |
| - | + | ||
Current revision
short form HGFA with first Kunitz domain from HAI-1
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Categories: Homo sapiens | Large Structures | Corpuz RT | Eigenbrot C | Fan B | Kirchhofer D | Lazarus RA | Santell L | Shia S | Stamos J | Wu J
