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1z2u

From Proteopedia

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[[Image:1z2u.gif|left|200px]]
 
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{{Structure
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==The 1.1A crystallographic structure of ubiquitin-conjugating enzyme (ubc-2) from Caenorhabditis elegans: functional and evolutionary significance==
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|PDB= 1z2u |SIZE=350|CAPTION= <scene name='initialview01'>1z2u</scene>, resolution 1.1&Aring;
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<StructureSection load='1z2u' size='340' side='right'caption='[[1z2u]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene> and <scene name='pdbligand=UNX:UNKNOWN ATOM OR ION'>UNX</scene>
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<table><tr><td colspan='2'>[[1z2u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z2U FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
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|GENE= ubc-2, let-70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z2u OCA], [https://pdbe.org/1z2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z2u RCSB], [https://www.ebi.ac.uk/pdbsum/1z2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z2u ProSAT], [https://www.topsan.org/Proteins/SECSG/1z2u TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UBC2_CAEEL UBC2_CAEEL] Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z2/1z2u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z2u ConSurf].
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<div style="clear:both"></div>
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'''The 1.1A crystallographic structure of ubiquitin-conjugating enzyme (ubc-2) from Caenorhabditis elegans: functional and evolutionary significance'''
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==See Also==
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*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1Z2U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z2U OCA].
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[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ubiquitin--protein ligase]]
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[[Category: DiGiamamarino E]]
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[[Category: DiGiamamarino, E.]]
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[[Category: Gavira JA]]
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[[Category: Gavira, J A.]]
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[[Category: Liu ZJ]]
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[[Category: Liu, Z J.]]
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[[Category: Meehan E]]
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[[Category: Meehan, E.]]
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[[Category: Ng JD]]
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[[Category: Ng, J D.]]
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[[Category: Tempel W]]
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[[Category: SECSG, Southeast Collaboratory for Structural Genomics.]]
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[[Category: Wang BC]]
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[[Category: Tempel, W.]]
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[[Category: Wang, B C.]]
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[[Category: BU3]]
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[[Category: CL]]
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[[Category: NA]]
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[[Category: UNX]]
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[[Category: caenorhabditis elegan]]
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[[Category: protein structure initiative]]
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[[Category: proteosome pathway]]
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[[Category: psi]]
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[[Category: secsg]]
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[[Category: southeast collaboratory for structural genomic]]
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[[Category: structural genomic]]
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[[Category: ubiquitin-conjugating enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:30:35 2008''
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Current revision

The 1.1A crystallographic structure of ubiquitin-conjugating enzyme (ubc-2) from Caenorhabditis elegans: functional and evolutionary significance

PDB ID 1z2u

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