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1z4r
From Proteopedia
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| - | [[Image:1z4r.png|left|200px]] | ||
| - | + | ==Human GCN5 Acetyltransferase== | |
| - | + | <StructureSection load='1z4r' size='340' side='right'caption='[[1z4r]], [[Resolution|resolution]] 1.74Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1z4r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z4R FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74Å</td></tr> | |
| - | == | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr> |
| - | [[1z4r]] is a 1 chain structure | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4r OCA], [https://pdbe.org/1z4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z4r RCSB], [https://www.ebi.ac.uk/pdbsum/1z4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z4r ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KAT2A_HUMAN KAT2A_HUMAN] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.<ref>PMID:17301242</ref> <ref>PMID:19103755</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/1z4r_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z4r ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Histone acetyltransferase|Histone acetyltransferase]] | + | *[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Antoshenko | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Antoshenko T]] |
| - | [[Category: Bernstein | + | [[Category: Arrowsmith C]] |
| - | [[Category: Bochkarev | + | [[Category: Bernstein G]] |
| - | [[Category: Dong | + | [[Category: Bochkarev A]] |
| - | [[Category: Edwards | + | [[Category: Dong A]] |
| - | [[Category: Loppnau | + | [[Category: Edwards A]] |
| - | [[Category: Plotnikov | + | [[Category: Loppnau P]] |
| - | + | [[Category: Plotnikov A]] | |
| - | [[Category: Schuetz | + | [[Category: Schuetz A]] |
| - | [[Category: Sundstrom | + | [[Category: Sundstrom M]] |
| - | [[Category: Wu | + | [[Category: Wu H]] |
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Current revision
Human GCN5 Acetyltransferase
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Categories: Homo sapiens | Large Structures | Antoshenko T | Arrowsmith C | Bernstein G | Bochkarev A | Dong A | Edwards A | Loppnau P | Plotnikov A | Schuetz A | Sundstrom M | Wu H
