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1z4r

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[[Image:1z4r.gif|left|200px]]
 
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==Human GCN5 Acetyltransferase==
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The line below this paragraph, containing "STRUCTURE_1z4r", creates the "Structure Box" on the page.
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<StructureSection load='1z4r' size='340' side='right'caption='[[1z4r]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1z4r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z4R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
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{{STRUCTURE_1z4r| PDB=1z4r | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4r OCA], [https://pdbe.org/1z4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z4r RCSB], [https://www.ebi.ac.uk/pdbsum/1z4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z4r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAT2A_HUMAN KAT2A_HUMAN] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.<ref>PMID:17301242</ref> <ref>PMID:19103755</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/1z4r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z4r ConSurf].
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<div style="clear:both"></div>
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'''Human GCN5 Acetyltransferase'''
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==See Also==
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*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1Z4R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4R OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A., Schuetz A, Bernstein G, Dong A, Antoshenko T, Wu H, Loppnau P, Bochkarev A, Plotnikov AN, Proteins. 2007 Jul 1;68(1):403-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17410582 17410582]
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[[Category: Histone acetyltransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Antoshenko, T.]]
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[[Category: Antoshenko T]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Bernstein, G.]]
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[[Category: Bernstein G]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Dong, A.]]
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[[Category: Dong A]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Loppnau, P.]]
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[[Category: Loppnau P]]
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[[Category: Plotnikov, A.]]
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[[Category: Plotnikov A]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Schuetz A]]
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[[Category: Schuetz, A.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Wu H]]
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[[Category: Wu, H.]]
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[[Category: Acetyltransferase]]
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[[Category: Gcn5]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 22:18:25 2008''
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Current revision

Human GCN5 Acetyltransferase

PDB ID 1z4r

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