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1z68

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==Crystal Structure Of Human Fibroblast Activation Protein alpha==
==Crystal Structure Of Human Fibroblast Activation Protein alpha==
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<StructureSection load='1z68' size='340' side='right' caption='[[1z68]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='1z68' size='340' side='right'caption='[[1z68]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1z68]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z68 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1z68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z68 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z68 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z68 RCSB], [http://www.ebi.ac.uk/pdbsum/1z68 PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z68 OCA], [https://pdbe.org/1z68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z68 RCSB], [https://www.ebi.ac.uk/pdbsum/1z68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z68 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SEPR_HUMAN SEPR_HUMAN] In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers.<ref>PMID:16651416</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/1z68_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/1z68_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z68 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1z68" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Aertgeerts, K.]]
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[[Category: Large Structures]]
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[[Category: Kraus, M L.]]
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[[Category: Aertgeerts K]]
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[[Category: Levin, I.]]
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[[Category: Kraus ML]]
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[[Category: Prasad, G S.]]
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[[Category: Levin I]]
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[[Category: Salakian, S.]]
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[[Category: Prasad GS]]
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[[Category: Shi, L.]]
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[[Category: Salakian S]]
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[[Category: Snell, G P.]]
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[[Category: Shi L]]
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[[Category: Sridhar, V.]]
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[[Category: Snell GP]]
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[[Category: Tennant, M G.]]
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[[Category: Sridhar V]]
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[[Category: Wijnands, R.]]
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[[Category: Tennant MG]]
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[[Category: Zhang, Y.]]
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[[Category: Wijnands R]]
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[[Category: Dipeptidylpeptidase]]
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[[Category: Zhang Y]]
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[[Category: Fapalpha]]
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[[Category: Fibroblast activation protein alpha]]
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[[Category: Integral membrane serine protease]]
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[[Category: Lyase]]
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[[Category: S9b]]
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[[Category: Seprase]]
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Current revision

Crystal Structure Of Human Fibroblast Activation Protein alpha

PDB ID 1z68

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