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1zsv

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==Crystal structure of human NADP-dependent leukotriene B4 12-hydroxydehydrogenase==
==Crystal structure of human NADP-dependent leukotriene B4 12-hydroxydehydrogenase==
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<StructureSection load='1zsv' size='340' side='right' caption='[[1zsv]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='1zsv' size='340' side='right'caption='[[1zsv]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1zsv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZSV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1zsv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZSV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LTB4DH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zsv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zsv RCSB], [http://www.ebi.ac.uk/pdbsum/1zsv PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zsv OCA], [https://pdbe.org/1zsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zsv RCSB], [https://www.ebi.ac.uk/pdbsum/1zsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zsv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LTB4D_HUMAN LTB4D_HUMAN]] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.
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[https://www.uniprot.org/uniprot/PTGR1_HUMAN PTGR1_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/1zsv_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/1zsv_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zsv ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C]]
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[[Category: Large Structures]]
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[[Category: Delft, F von]]
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[[Category: Arrowsmith C]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Guo, K]]
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[[Category: Guo K]]
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[[Category: Johansson, C]]
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[[Category: Johansson C]]
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[[Category: Oppermann, U]]
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[[Category: Oppermann U]]
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[[Category: Structural genomic]]
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[[Category: Savitsky P]]
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[[Category: Savitsky, P]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M]]
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[[Category: Turnbull AP]]
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[[Category: Turnbull, A P]]
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[[Category: Von Delft F]]
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[[Category: Human]]
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[[Category: Leukotriene b4]]
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[[Category: Medium-chain dehydrogenase/reductase family]]
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[[Category: Oxidoreductase]]
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[[Category: Sgc]]
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Current revision

Crystal structure of human NADP-dependent leukotriene B4 12-hydroxydehydrogenase

PDB ID 1zsv

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