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1zw1

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==Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives==
==Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives==
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<StructureSection load='1zw1' size='340' side='right' caption='[[1zw1]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='1zw1' size='340' side='right'caption='[[1zw1]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1zw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZW1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1zw1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZW1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TN5:2-(4-AMINO-2-CHLOROPHENOXY)-5-CHLOROPHENOL'>TN5</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nhd|1nhd]], [[1nhg|1nhg]], [[1nhw|1nhw]], [[1nnu|1nnu]], [[1zsn|1zsn]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TN5:2-(4-AMINO-2-CHLOROPHENOXY)-5-CHLOROPHENOL'>TN5</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PfENR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zw1 OCA], [https://pdbe.org/1zw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zw1 RCSB], [https://www.ebi.ac.uk/pdbsum/1zw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zw1 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zw1 OCA], [http://pdbe.org/1zw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zw1 RCSB], [http://www.ebi.ac.uk/pdbsum/1zw1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zw1 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9BH77_PLAFA Q9BH77_PLAFA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1zw1" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1zw1" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Plafa]]
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[[Category: Large Structures]]
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[[Category: Anderson, J W]]
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[[Category: Plasmodium falciparum]]
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[[Category: Fidock, D A]]
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[[Category: Anderson JW]]
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[[Category: Freundlich, J S]]
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[[Category: Fidock DA]]
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[[Category: Jacobs, W R]]
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[[Category: Freundlich JS]]
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[[Category: Jacobus, D P]]
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[[Category: Jacobs Jr WR]]
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[[Category: Kuo, M]]
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[[Category: Jacobus DP]]
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[[Category: Lucumi, E]]
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[[Category: Kuo M]]
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[[Category: Sacchettini, J C]]
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[[Category: Lucumi E]]
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[[Category: Sarantakis, D]]
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[[Category: Sacchettini JC]]
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[[Category: Schiehser, G A]]
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[[Category: Sarantakis D]]
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[[Category: Shieh, H M]]
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[[Category: Schiehser GA]]
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[[Category: Yu, M]]
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[[Category: Shieh HM]]
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[[Category: Oxidoreductase]]
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[[Category: Yu M]]

Current revision

Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives

PDB ID 1zw1

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