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1zxt

From Proteopedia

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Crystal Structure of A Viral Chemokine

Structural highlights

1zxt is a 4 chain structure with sequence from Human gammaherpesvirus 8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.7Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q76RJ0_HHV8

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Viral macrophage inflammatory protein I (vMIP-I) is a chemokine encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) that selectively activates the CC chemokine receptor 8 (CCR8), for which the endogenous ligand is CCL1. The crystal structure of vMIP-I was determined at 1.7A for comparison with other chemokines, especially those that bind CCR8, such as vMIP-II from KSHV, a CCR8 antagonist and the closest homolog (40% identical). vMIP-I has a typical chemokine fold consisting of an extended N-terminal loop, followed by a three-stranded antiparallel beta-sheet and a C-terminal alpha-helix. The four molecules in the asymmetric unit comprise two MIP-1beta-like dimers. Electrostatic surface representations of CCR8-binding chemokines reveal only minor areas of correlating surface potential, which must be reconciled with promiscuity in receptor and glycosaminoglycan (GAG) binding. In addition, the biological relevance of chemokine oligomerization is examined by comparing the oligomeric states of all chemokine structures deposited to date in the RCSB PDB.

Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7A.,Luz JG, Yu M, Su Y, Wu Z, Zhou Z, Sun R, Wilson IA J Mol Biol. 2005 Oct 7;352(5):1019-28. PMID:16140327^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Luz JG, Yu M, Su Y, Wu Z, Zhou Z, Sun R, Wilson IA. Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7A. J Mol Biol. 2005 Oct 7;352(5):1019-28. PMID:16140327 doi:10.1016/j.jmb.2005.08.011

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zxt"

@@ Line 3: / Line 3: @@
 <StructureSection load='1zxt' size='340' side='right'caption='[[1zxt]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1zxt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-8 Hhv-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZXT FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1zxt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZXT FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxt OCA], [http://pdbe.org/1zxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zxt RCSB], [http://www.ebi.ac.uk/pdbsum/1zxt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zxt ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxt OCA], [https://pdbe.org/1zxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zxt RCSB], [https://www.ebi.ac.uk/pdbsum/1zxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zxt ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q76RJ0_HHV8 Q76RJ0_HHV8]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 29: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Hhv-8]]
+[[Category: Human gammaherpesvirus 8]]
 [[Category: Large Structures]]
-[[Category: Luz, J G]]
+[[Category: Luz JG]]
-[[Category: Su, Y]]
+[[Category: Su Y]]
-[[Category: Sun, R]]
+[[Category: Sun R]]
-[[Category: Wilson, I A]]
+[[Category: Wilson IA]]
-[[Category: Wu, Z]]
+[[Category: Wu Z]]
-[[Category: Yu, M]]
+[[Category: Yu M]]
-[[Category: Zhou, Z]]
+[[Category: Zhou Z]]
-[[Category: Chemokine fold]]
-[[Category: Greek key motif]]
-[[Category: Signaling protein]]

1zxt

From Proteopedia

Current revision

Crystal Structure of A Viral Chemokine

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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