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2aip

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==Crystal structure of native protein C activator from the venom of copperhead snake Agkistrodon contortrix contortrix==
==Crystal structure of native protein C activator from the venom of copperhead snake Agkistrodon contortrix contortrix==
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<StructureSection load='2aip' size='340' side='right' caption='[[2aip]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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<StructureSection load='2aip' size='340' side='right'caption='[[2aip]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2aip]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Agkistrodon_contortrix_contortrix Agkistrodon contortrix contortrix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AIP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2aip]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Agkistrodon_contortrix_contortrix Agkistrodon contortrix contortrix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AIP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Venombin_A Venombin A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.74 3.4.21.74] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aip OCA], [http://pdbe.org/2aip PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aip RCSB], [http://www.ebi.ac.uk/pdbsum/2aip PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2aip ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aip OCA], [https://pdbe.org/2aip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aip RCSB], [https://www.ebi.ac.uk/pdbsum/2aip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aip ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VSPCA_AGKCO VSPCA_AGKCO]] Snake venom serine protease that selectively cleaves the heavy chain of protein C (PROC). This activation is thrombomodulin-independent.<ref>PMID:3624272</ref>
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[https://www.uniprot.org/uniprot/VSPCA_AGKCO VSPCA_AGKCO] Snake venom serine protease that selectively cleaves the heavy chain of protein C (PROC). This activation is thrombomodulin-independent.<ref>PMID:3624272</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Agkistrodon contortrix contortrix]]
[[Category: Agkistrodon contortrix contortrix]]
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[[Category: Venombin A]]
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[[Category: Large Structures]]
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[[Category: Arni, R K]]
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[[Category: Arni RK]]
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[[Category: Murakami, M T]]
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[[Category: Murakami MT]]
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[[Category: Hydrolase]]
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[[Category: Protein c activator]]
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[[Category: Snake venom]]
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[[Category: Trypsin-like enzyme]]
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Current revision

Crystal structure of native protein C activator from the venom of copperhead snake Agkistrodon contortrix contortrix

PDB ID 2aip

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