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2al0

From Proteopedia

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[[Image:2al0.png|left|200px]]
 
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{{STRUCTURE_2al0| PDB=2al0 | SCENE= }}
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==Crystal structure of nitrophorin 2 ferrous aqua complex==
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<StructureSection load='2al0' size='340' side='right'caption='[[2al0]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2al0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AL0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2al0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2al0 OCA], [https://pdbe.org/2al0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2al0 RCSB], [https://www.ebi.ac.uk/pdbsum/2al0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2al0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NP2_RHOPR NP2_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity). Specifically inhibits factor IXa-catalyzed activation of factor X in the presence of calcium and phospholipids irrespective of the presence or absence of factor VIIIa.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/al/2al0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2al0 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of nitrophorin 2 ferrous aqua complex===
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==See Also==
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*[[Nitrophorin|Nitrophorin]]
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{{ABSTRACT_PUBMED_10884386}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2al0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AL0 OCA].
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==Reference==
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<ref group="xtra">PMID:010884386</ref><ref group="xtra">PMID:019140692</ref><references group="xtra"/>
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[[Category: Rhodnius prolixus]]
[[Category: Rhodnius prolixus]]
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[[Category: Berry, R E.]]
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[[Category: Berry RE]]
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[[Category: Montfort, W R.]]
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[[Category: Montfort WR]]
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[[Category: Walker, F A.]]
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[[Category: Walker FA]]
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[[Category: Weichsel, A.]]
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[[Category: Weichsel A]]
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[[Category: Beta barrel]]
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[[Category: Ferrous heme]]
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[[Category: Lipocalin]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of nitrophorin 2 ferrous aqua complex

PDB ID 2al0

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