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2amm

From Proteopedia

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{{Seed}}
 
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[[Image:2amm.png|left|200px]]
 
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==Crystal structure of L122V/L132V mutant of nitrophorin 2==
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The line below this paragraph, containing "STRUCTURE_2amm", creates the "Structure Box" on the page.
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<StructureSection load='2amm' size='340' side='right'caption='[[2amm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2amm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AMM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AMM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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{{STRUCTURE_2amm| PDB=2amm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2amm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2amm OCA], [https://pdbe.org/2amm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2amm RCSB], [https://www.ebi.ac.uk/pdbsum/2amm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2amm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NP2_RHOPR NP2_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity). Specifically inhibits factor IXa-catalyzed activation of factor X in the presence of calcium and phospholipids irrespective of the presence or absence of factor VIIIa.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/am/2amm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2amm ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of L122V/L132V mutant of nitrophorin 2===
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==See Also==
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*[[Nitrophorin|Nitrophorin]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2AMM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AMM OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:10884386</ref><references group="xtra"/>
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[[Category: Rhodnius prolixus]]
[[Category: Rhodnius prolixus]]
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[[Category: Berry, R E.]]
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[[Category: Berry RE]]
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[[Category: Montfort, W R.]]
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[[Category: Montfort WR]]
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[[Category: Walker, F A.]]
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[[Category: Walker FA]]
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[[Category: Weichsel, A.]]
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[[Category: Weichsel A]]
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[[Category: Beta barrel]]
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[[Category: Double mutant]]
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[[Category: Ferric heme]]
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[[Category: Lipocalin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:41:13 2009''
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Current revision

Crystal structure of L122V/L132V mutant of nitrophorin 2

PDB ID 2amm

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