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2awg

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==Structure of the PPIase domain of the Human FK506-binding protein 8==
==Structure of the PPIase domain of the Human FK506-binding protein 8==
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<StructureSection load='2awg' size='340' side='right' caption='[[2awg]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='2awg' size='340' side='right'caption='[[2awg]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2awg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AWG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2awg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AWG FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FKBP8, FKBP38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2awg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2awg OCA], [http://pdbe.org/2awg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2awg RCSB], [http://www.ebi.ac.uk/pdbsum/2awg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2awg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2awg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2awg OCA], [https://pdbe.org/2awg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2awg RCSB], [https://www.ebi.ac.uk/pdbsum/2awg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2awg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FKBP8_HUMAN FKBP8_HUMAN]] Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.<ref>PMID:12510191</ref> <ref>PMID:16176796</ref> <ref>PMID:15757646</ref>
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[https://www.uniprot.org/uniprot/FKBP8_HUMAN FKBP8_HUMAN] Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.<ref>PMID:12510191</ref> <ref>PMID:16176796</ref> <ref>PMID:15757646</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[FK506 binding protein|FK506 binding protein]]
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*[[FKBP 3D structures|FKBP 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A]]
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[[Category: Arrowsmith C]]
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[[Category: Davis, T]]
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[[Category: Bochkarev A]]
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[[Category: Dhe-Paganon, S]]
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[[Category: Davis T]]
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[[Category: Edwards, A]]
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[[Category: Dhe-Paganon S]]
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[[Category: Finerty, P]]
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[[Category: Edwards A]]
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[[Category: Mackenzie, F]]
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[[Category: Finerty P]]
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[[Category: Newman, E M]]
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[[Category: Mackenzie F]]
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[[Category: Structural genomic]]
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[[Category: Newman EM]]
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[[Category: Sundstrom, M]]
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[[Category: Sundstrom M]]
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[[Category: Walker, J R]]
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[[Category: Walker JR]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Bcl-2 inhibitor]]
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[[Category: Fkbp-type]]
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[[Category: Ppiase]]
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[[Category: Sgc]]
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[[Category: Shh signalling antagonist]]
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[[Category: Signaling protein inhibitor]]
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Current revision

Structure of the PPIase domain of the Human FK506-binding protein 8

PDB ID 2awg

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