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2f5y

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==Crystal Structure of the PDZ Domain from Human RGS-3==
==Crystal Structure of the PDZ Domain from Human RGS-3==
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<StructureSection load='2f5y' size='340' side='right' caption='[[2f5y]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
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<StructureSection load='2f5y' size='340' side='right'caption='[[2f5y]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2f5y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2f5y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F5Y FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1i92|1i92]], [[1qau|1qau]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RGS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5y OCA], [https://pdbe.org/2f5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f5y RCSB], [https://www.ebi.ac.uk/pdbsum/2f5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f5y ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f5y RCSB], [http://www.ebi.ac.uk/pdbsum/2f5y PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/RGS3_HUMAN RGS3_HUMAN] Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.<ref>PMID:8602223</ref> <ref>PMID:9858594</ref> <ref>PMID:10749886</ref> <ref>PMID:11294858</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/2f5y_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/2f5y_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f5y ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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==See Also==
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*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Berridge, G.]]
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[[Category: Arrowsmith C]]
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[[Category: Bunkoczi, G.]]
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[[Category: Berridge G]]
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[[Category: Burgess, N.]]
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[[Category: Bunkoczi G]]
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[[Category: Colebrook, S.]]
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[[Category: Burgess N]]
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[[Category: Debreczeni, J.]]
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[[Category: Colebrook S]]
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[[Category: Delft, F von.]]
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[[Category: Debreczeni J]]
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[[Category: Doyle, D.]]
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[[Category: Doyle D]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Elkins, J.]]
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[[Category: Elkins J]]
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[[Category: Gorrec, F.]]
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[[Category: Gorrec F]]
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[[Category: Johansson, C.]]
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[[Category: Johansson C]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Papagrigoriou E]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Savitsky P]]
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[[Category: Savitsky, P.]]
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[[Category: Smee C]]
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[[Category: Smee, C.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Turnbull A]]
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[[Category: Turnbull, A.]]
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[[Category: Ugochukwu E]]
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[[Category: Ugochukwu, E.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Yang X]]
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[[Category: Yang, X.]]
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[[Category: Von Delft F]]
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[[Category: Human]]
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[[Category: Pdz domain]]
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[[Category: Rgs-3]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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Current revision

Crystal Structure of the PDZ Domain from Human RGS-3

PDB ID 2f5y

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