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2xn8

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==X-RAY STRUCTURE OF THE SUBSTRATE-FREE MYCOBACTERIUM TUBERCULOSIS CYTOCHROME P450 CYP125==
==X-RAY STRUCTURE OF THE SUBSTRATE-FREE MYCOBACTERIUM TUBERCULOSIS CYTOCHROME P450 CYP125==
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<StructureSection load='2xn8' size='340' side='right' caption='[[2xn8]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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<StructureSection load='2xn8' size='340' side='right'caption='[[2xn8]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xn8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XN8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xn8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XN8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2x5w|2x5w]], [[2xc3|2xc3]], [[2x5l|2x5l]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xn8 OCA], [http://pdbe.org/2xn8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xn8 RCSB], [http://www.ebi.ac.uk/pdbsum/2xn8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xn8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xn8 OCA], [https://pdbe.org/2xn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xn8 RCSB], [https://www.ebi.ac.uk/pdbsum/2xn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xn8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CP125_MYCTU CP125_MYCTU]] Catalyzes the C-27 hydroxylation of cholest-4-en-3-one and cholesterol and subsequently oxidizes the alcohol of the former to the cholest-4-en-3-one-27-oic acid via the aldehyde intermediate. Not required to incorporate the cholesterol side-chain carbon atoms into cellular lipids.<ref>PMID:19846551</ref> <ref>PMID:20545858</ref>
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[https://www.uniprot.org/uniprot/CP125_MYCTU CP125_MYCTU] Catalyzes the C-27 hydroxylation of cholest-4-en-3-one and cholesterol and subsequently oxidizes the alcohol of the former to the cholest-4-en-3-one-27-oic acid via the aldehyde intermediate. Not required to incorporate the cholesterol side-chain carbon atoms into cellular lipids.<ref>PMID:19846551</ref> <ref>PMID:20545858</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Myctu]]
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[[Category: Large Structures]]
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[[Category: Kells, P M]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Montellano, P R.Ortiz de]]
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[[Category: Kells PM]]
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[[Category: Ouellet, H]]
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[[Category: Ortiz de Montellano PR]]
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[[Category: Podust, L M]]
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[[Category: Ouellet H]]
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[[Category: Cholesterol degradation]]
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[[Category: Podust LM]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: Reverse type i inhibitor]]
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Current revision

X-RAY STRUCTURE OF THE SUBSTRATE-FREE MYCOBACTERIUM TUBERCULOSIS CYTOCHROME P450 CYP125

PDB ID 2xn8

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