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2xpu

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==TetR(D) in complex with anhydrotetracycline.==
==TetR(D) in complex with anhydrotetracycline.==
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<StructureSection load='2xpu' size='340' side='right' caption='[[2xpu]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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<StructureSection load='2xpu' size='340' side='right'caption='[[2xpu]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xpu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XPU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xpu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XPU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TDC:5A,6-ANHYDROTETRACYCLINE'>TDC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xgc|2xgc]], [[2xpw|2xpw]], [[3zqg|3zqg]], [[2x9d|2x9d]], [[1bjz|1bjz]], [[3zqh|3zqh]], [[2trt|2trt]], [[2xpv|2xpv]], [[2vkv|2vkv]], [[1ork|1ork]], [[2xge|2xge]], [[1a6i|1a6i]], [[2x6o|2x6o]], [[2vke|2vke]], [[1qpi|1qpi]], [[1du7|1du7]], [[2xgd|2xgd]], [[2xrl|2xrl]], [[2xpt|2xpt]], [[2xb5|2xb5]], [[2xps|2xps]], [[1bj0|1bj0]], [[3zqf|3zqf]], [[3zqi|3zqi]], [[2tct|2tct]], [[1bjy|1bjy]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TDC:5A,6-ANHYDROTETRACYCLINE'>TDC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xpu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xpu RCSB], [http://www.ebi.ac.uk/pdbsum/2xpu PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xpu OCA], [https://pdbe.org/2xpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xpu RCSB], [https://www.ebi.ac.uk/pdbsum/2xpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xpu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX]] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
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[https://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2xpu" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Tetracycline repressor protein|Tetracycline repressor protein]]
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*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Dalm, D]]
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[[Category: Large Structures]]
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[[Category: Hinrichs, W]]
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[[Category: Dalm D]]
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[[Category: Palm, G J]]
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[[Category: Hinrichs W]]
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[[Category: Helix-turn-helix]]
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[[Category: Palm GJ]]
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[[Category: Metal coordination]]
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[[Category: Transcription]]
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[[Category: Transcription regulator]]
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Current revision

TetR(D) in complex with anhydrotetracycline.

PDB ID 2xpu

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