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2y3s

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==STRUCTURE OF THE TIRANDAMYCINE-BOUND FAD-DEPENDENT TIRANDAMYCIN OXIDASE TAML IN C2 SPACE GROUP==
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<StructureSection load='2y3s' size='340' side='right' caption='[[2y3s]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
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==Structure of the tirandamycine-bound FAD-dependent tirandamycin oxidase TamL in C2 space group==
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<StructureSection load='2y3s' size='340' side='right'caption='[[2y3s]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2y3s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp._307-9 Streptomyces sp. 307-9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3S OCA]. <br>
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<table><tr><td colspan='2'>[[2y3s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp._307-9 Streptomyces sp. 307-9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y3S FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TIR:TIRANDAMYCIN+E'>TIR</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2y3r|2y3r]], [[2y4g|2y4g]], [[2y08|2y08]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TIR:TIRANDAMYCIN+E'>TIR</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3s OCA], [https://pdbe.org/2y3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y3s RCSB], [https://www.ebi.ac.uk/pdbsum/2y3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y3s ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y3s RCSB], [http://www.ebi.ac.uk/pdbsum/2y3s PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/D3Y1I2_9ACTN D3Y1I2_9ACTN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes.,Carlson JC, Li S, Gunatilleke SS, Anzai Y, Burr DA, Podust LM, Sherman DH Nat Chem. 2011 Jul 17;3(8):628-33. doi: 10.1038/nchem.1087. PMID:21778983<ref>PMID:21778983</ref>
Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes.,Carlson JC, Li S, Gunatilleke SS, Anzai Y, Burr DA, Podust LM, Sherman DH Nat Chem. 2011 Jul 17;3(8):628-33. doi: 10.1038/nchem.1087. PMID:21778983<ref>PMID:21778983</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2y3s" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptomyces sp. 307-9]]
[[Category: Streptomyces sp. 307-9]]
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[[Category: Anzai, Y.]]
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[[Category: Anzai Y]]
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[[Category: Burr, D A.]]
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[[Category: Burr DA]]
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[[Category: Carlson, J C.]]
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[[Category: Carlson JC]]
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[[Category: Gunatilleke, S S.]]
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[[Category: Gunatilleke SS]]
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[[Category: Li, S.]]
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[[Category: Li S]]
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[[Category: Podust, L M.]]
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[[Category: Podust LM]]
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[[Category: Sherman, D H.]]
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[[Category: Sherman DH]]
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[[Category: Oxidoreductase]]
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Current revision

Structure of the tirandamycine-bound FAD-dependent tirandamycin oxidase TamL in C2 space group

PDB ID 2y3s

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