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2y5t

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==CRYSTAL STRUCTURE OF THE PATHOGENIC AUTOANTIBODY CIIC1 IN COMPLEX WITH THE TRIPLE-HELICAL C1 PEPTIDE==
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<StructureSection load='2y5t' size='340' side='right' caption='[[2y5t]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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==Crystal structure of the pathogenic autoantibody CIIC1 in complex with the triple-helical C1 peptide==
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<StructureSection load='2y5t' size='340' side='right'caption='[[2y5t]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2y5t]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y5T OCA]. <br>
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<table><tr><td colspan='2'>[[2y5t]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y5T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y5T FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y5t OCA], [https://pdbe.org/2y5t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y5t RCSB], [https://www.ebi.ac.uk/pdbsum/2y5t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y5t ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y5t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y5t RCSB], [http://www.ebi.ac.uk/pdbsum/2y5t PDBsum]</span></td></tr>
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</table>
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<table>
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<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Crystal structure of an arthritogenic anticollagen immune complex.,Dobritzsch D, Lindh I, Uysal H, Nandakumar KS, Burkhardt H, Schneider G, Holmdahl R Arthritis Rheum. 2011 Dec;63(12):3740-8. doi: 10.1002/art.30611. PMID:22127694<ref>PMID:22127694</ref>
Crystal structure of an arthritogenic anticollagen immune complex.,Dobritzsch D, Lindh I, Uysal H, Nandakumar KS, Burkhardt H, Schneider G, Holmdahl R Arthritis Rheum. 2011 Dec;63(12):3740-8. doi: 10.1002/art.30611. PMID:22127694<ref>PMID:22127694</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2y5t" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Burkhardt, H.]]
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[[Category: Burkhardt H]]
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[[Category: Dobritzsch, D.]]
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[[Category: Dobritzsch D]]
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[[Category: Holmdahl, R.]]
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[[Category: Holmdahl R]]
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[[Category: Lindh, I.]]
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[[Category: Lindh I]]
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[[Category: Nandakumar, K S.]]
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[[Category: Nandakumar KS]]
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[[Category: Schneider, G.]]
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[[Category: Schneider G]]
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[[Category: Schneider, N.]]
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[[Category: Schneider N]]
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[[Category: Uysal, H.]]
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[[Category: Uysal H]]
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[[Category: Antibody]]
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[[Category: Arthritogenic]]
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[[Category: Immune system]]
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[[Category: Rheumatoid arthritis]]
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Current revision

Crystal structure of the pathogenic autoantibody CIIC1 in complex with the triple-helical C1 peptide

PDB ID 2y5t

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