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2yb8

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==CRYSTAL STRUCTURE OF NURF55 IN COMPLEX WITH SU(Z)12==
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==Crystal structure of Nurf55 in complex with Su(z)12==
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<StructureSection load='2yb8' size='340' side='right' caption='[[2yb8]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='2yb8' size='340' side='right'caption='[[2yb8]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yb8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YB8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2yb8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YB8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xyi|2xyi]], [[2yba|2yba]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yb8 OCA], [http://pdbe.org/2yb8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yb8 RCSB], [http://www.ebi.ac.uk/pdbsum/2yb8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yb8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yb8 OCA], [https://pdbe.org/2yb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yb8 RCSB], [https://www.ebi.ac.uk/pdbsum/2yb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yb8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SUZ12_DROME SUZ12_DROME]] Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required. [[http://www.uniprot.org/uniprot/CAF1_DROME CAF1_DROME]] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the nucleosome remodeling factor (NURF) complex, which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin; and the polycomb group (PcG) repressor complex ESC-E(Z), which promotes repression of homeotic genes during development. Also required for transcriptional repression of E2F target genes by E2f2 and Rbf or Rbf2.<ref>PMID:8887645</ref> <ref>PMID:9419341</ref> <ref>PMID:9784495</ref> <ref>PMID:12490953</ref> <ref>PMID:15456884</ref>
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[https://www.uniprot.org/uniprot/SUZ12_DROME SUZ12_DROME] Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 2yb8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2yb8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Polycomb complex proteins 3D structures|Polycomb complex proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drome]]
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[[Category: Drosophila melanogaster]]
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[[Category: Aiwazian, J]]
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[[Category: Large Structures]]
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[[Category: Bauer, A]]
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[[Category: Aiwazian J]]
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[[Category: Bouwmeester, T]]
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[[Category: Bauer A]]
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[[Category: Bunker, R D]]
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[[Category: Bouwmeester T]]
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[[Category: Chan, H]]
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[[Category: Bunker RD]]
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[[Category: Faty, M]]
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[[Category: Chan H]]
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[[Category: Fischle, W]]
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[[Category: Faty M]]
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[[Category: Gu, J]]
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[[Category: Fischle W]]
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[[Category: Gut, H]]
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[[Category: Gu J]]
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[[Category: Hess, D]]
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[[Category: Gut H]]
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[[Category: Li, L]]
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[[Category: Hess D]]
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[[Category: Lingaraju, G M]]
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[[Category: Li L]]
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[[Category: Ly-Hartig, N]]
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[[Category: Lingaraju GM]]
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[[Category: Muller, J]]
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[[Category: Ly-Hartig N]]
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[[Category: Prusty, A B]]
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[[Category: Muller J]]
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[[Category: Sack, R]]
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[[Category: Prusty AB]]
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[[Category: Schmitges, F W]]
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[[Category: Sack R]]
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[[Category: Stutzer, A]]
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[[Category: Schmitges FW]]
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[[Category: Thoma, N H]]
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[[Category: Stutzer A]]
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[[Category: Wirth, U]]
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[[Category: Thoma NH]]
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[[Category: Zhao, K]]
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[[Category: Wirth U]]
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[[Category: Zhou, S]]
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[[Category: Zhao K]]
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[[Category: Chromatin remodelling]]
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[[Category: Zhou S]]
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[[Category: H3k27]]
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[[Category: H3k4]]
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[[Category: H4]]
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[[Category: Histone methlyation]]
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[[Category: P55]]
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[[Category: Prc2]]
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[[Category: Rbap46]]
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[[Category: Rbap48]]
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[[Category: Rbbp4]]
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[[Category: Rbbp7]]
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[[Category: Transcription]]
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[[Category: Wd40 domain]]
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Current revision

Crystal structure of Nurf55 in complex with Su(z)12

PDB ID 2yb8

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