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2ykd

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==STRUCTURE OF THE MATRIX PROTEIN FROM HUMAN RESPIRATORY SYNCYTIAL VIRUS==
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<StructureSection load='2ykd' size='340' side='right' caption='[[2ykd]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
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==Structure of the matrix protein from human respiratory syncytial virus==
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<StructureSection load='2ykd' size='340' side='right'caption='[[2ykd]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ykd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_respiratory_syncytial_virus Human respiratory syncytial virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YKD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ykd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_orthopneumovirus Human orthopneumovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YKD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vqp|2vqp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ykd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ykd RCSB], [http://www.ebi.ac.uk/pdbsum/2ykd PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ykd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykd OCA], [https://pdbe.org/2ykd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ykd RCSB], [https://www.ebi.ac.uk/pdbsum/2ykd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ykd ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MATRX_HRSVA MATRX_HRSVA] Has a crucial role in virus assembly and budding. The matrix interacts with the RNP complex and this association serves two functions: facilitate virion assembly and inhibit the viral transcriptase activity. Early in infection, M is localized to the nucleus and may inhibit host cell transcription. Later on, M can associate with lipid rafts supposely by interacting with the cytoskeleton and with the cytoplasmic tail of glycoprotein G. The binding of M to host membrane is stabilized by the surface expression of the viral glycoproteins. These interactions may allow virus formation by mediating association of the nucleocapsid with the nascent envelop.<ref>PMID:11907323</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2ykd" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human respiratory syncytial virus]]
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[[Category: Human orthopneumovirus]]
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[[Category: Beeby, A]]
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[[Category: Large Structures]]
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[[Category: Carlisle, J L]]
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[[Category: Beeby A]]
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[[Category: Mcphee, H K]]
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[[Category: Carlisle JL]]
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[[Category: Money, V A]]
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[[Category: McPhee HK]]
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[[Category: Sanderson, J M]]
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[[Category: Money VA]]
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[[Category: Watson, S M.D]]
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[[Category: Sanderson JM]]
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[[Category: Yeo, R P]]
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[[Category: Watson SMD]]
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[[Category: Peripheral membrane protein]]
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[[Category: Yeo RP]]
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[[Category: Viral matrix protein]]
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[[Category: Viral protein]]
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[[Category: Virion]]
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Current revision

Structure of the matrix protein from human respiratory syncytial virus

PDB ID 2ykd

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