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2f91

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==1.2A resolution structure of a crayfish trypsin complexed with a peptide inhibitor, SGTI==
==1.2A resolution structure of a crayfish trypsin complexed with a peptide inhibitor, SGTI==
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<StructureSection load='2f91' size='340' side='right' caption='[[2f91]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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<StructureSection load='2f91' size='340' side='right'caption='[[2f91]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2f91]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pontastacus_leptodactylus Pontastacus leptodactylus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1yr4 1yr4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F91 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F91 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2f91]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Astacus_leptodactylus Astacus leptodactylus] and [https://en.wikipedia.org/wiki/Schistocerca_gregaria Schistocerca gregaria]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1yr4 1yr4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F91 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f91 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f91 RCSB], [http://www.ebi.ac.uk/pdbsum/2f91 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f91 OCA], [https://pdbe.org/2f91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f91 RCSB], [https://www.ebi.ac.uk/pdbsum/2f91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f91 ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q52V24_ASTLP Q52V24_ASTLP]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/2f91_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/2f91_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f91 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2f91" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Trypsin|Trypsin]]
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*[[Trypsin 3D structures|Trypsin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pontastacus leptodactylus]]
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[[Category: Astacus leptodactylus]]
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[[Category: Trypsin]]
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[[Category: Large Structures]]
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[[Category: Antal, J.]]
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[[Category: Schistocerca gregaria]]
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[[Category: Fodor, K.]]
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[[Category: Antal J]]
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[[Category: Graf, L.]]
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[[Category: Fodor K]]
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[[Category: Harmat, V.]]
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[[Category: Graf L]]
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[[Category: Hetenyi, C.]]
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[[Category: Harmat V]]
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[[Category: Kardos, J.]]
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[[Category: Hetenyi C]]
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[[Category: Katona, G.]]
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[[Category: Kardos J]]
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[[Category: Patthy, A.]]
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[[Category: Katona G]]
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[[Category: Perczel, A.]]
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[[Category: Patthy A]]
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[[Category: Atomic resolution]]
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[[Category: Perczel A]]
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[[Category: Canonical inhibitor]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Serine protease]]
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[[Category: Trypsin]]
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Current revision

1.2A resolution structure of a crayfish trypsin complexed with a peptide inhibitor, SGTI

PDB ID 2f91

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