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2flu

From Proteopedia

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<StructureSection load='2flu' size='340' side='right'caption='[[2flu]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='2flu' size='340' side='right'caption='[[2flu]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2flu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FLU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2flu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FLU FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u6d|1u6d]], [[1zgk|1zgk]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2flu OCA], [http://pdbe.org/2flu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2flu RCSB], [http://www.ebi.ac.uk/pdbsum/2flu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2flu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2flu OCA], [https://pdbe.org/2flu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2flu RCSB], [https://www.ebi.ac.uk/pdbsum/2flu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2flu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NF2L2_HUMAN NF2L2_HUMAN]] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.<ref>PMID:11035812</ref>
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[https://www.uniprot.org/uniprot/KEAP1_HUMAN KEAP1_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Beamer, L]]
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[[Category: Beamer L]]
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[[Category: Hannink, M]]
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[[Category: Hannink M]]
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[[Category: Li, X]]
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[[Category: Li X]]
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[[Category: Lo, J]]
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[[Category: Lo J]]
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[[Category: Beta-propeller]]
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[[Category: Kelch domain]]
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[[Category: Ligase]]
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[[Category: Protein-peptide complex]]
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Current revision

Crystal Structure of the Kelch-Neh2 Complex

PDB ID 2flu

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OCA

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