This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2fot
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='2fot' size='340' side='right'caption='[[2fot]], [[Resolution|resolution]] 2.45Å' scene=''> | <StructureSection load='2fot' size='340' side='right'caption='[[2fot]], [[Resolution|resolution]] 2.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2fot]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2fot]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FOT FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fot OCA], [https://pdbe.org/2fot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fot RCSB], [https://www.ebi.ac.uk/pdbsum/2fot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fot ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fot OCA], [https://pdbe.org/2fot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fot RCSB], [https://www.ebi.ac.uk/pdbsum/2fot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fot ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [[https://www.uniprot.org/uniprot/SPTN1_HUMAN SPTN1_HUMAN]] West syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/CALM_BOVIN CALM_BOVIN] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 35: | Line 32: | ||
==See Also== | ==See Also== | ||
*[[Calmodulin 3D structures|Calmodulin 3D structures]] | *[[Calmodulin 3D structures|Calmodulin 3D structures]] | ||
| - | *[[Spectrin|Spectrin]] | + | *[[Spectrin 3D structures|Spectrin 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
| Line 41: | Line 38: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Cianci | + | [[Category: Cianci CD]] |
| - | [[Category: Morrow | + | [[Category: Morrow JS]] |
| - | [[Category: Simonovic | + | [[Category: Simonovic M]] |
| - | [[Category: Steitz | + | [[Category: Steitz TA]] |
| - | [[Category: Zhang | + | [[Category: Zhang Z]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal structure of the complex between calmodulin and alphaII-spectrin
| |||||||||||
