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2gzi

From Proteopedia

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[[Image:2gzi.png|left|200px]]
 
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{{STRUCTURE_2gzi| PDB=2gzi | SCENE= }}
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==Crystal Structure of the E9 DNase Domain with a Mutant Immunity Protein IM9 (V34A)==
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<StructureSection load='2gzi' size='340' side='right'caption='[[2gzi]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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===Crystal Structure of the E9 DNase Domain with a Mutant Immunity Protein IM9 (V34A)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2gzi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GZI FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10074943}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gzi OCA], [https://pdbe.org/2gzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gzi RCSB], [https://www.ebi.ac.uk/pdbsum/2gzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gzi ProSAT]</span></td></tr>
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[[2gzi]] is a 2 chain structure of [[Colicin]] and [[Colicin Immunity Protein]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k12 Escherichia coli k12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GZI OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IMM9_ECOLX IMM9_ECOLX] This protein is able to protect a cell, which harbors the plasmid ColE9 encoding colicin E9, against colicin E9, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/2gzi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gzi ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Colicin|Colicin]]
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*[[Colicin 3D structures|Colicin 3D structures]]
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*[[Colicin Immunity Protein|Colicin Immunity Protein]]
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*[[Colicin immunity protein 3D structures|Colicin immunity protein 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010074943</ref><references group="xtra"/>
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[[Category: Escherichia coli K-12]]
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[[Category: Deoxyribonuclease I]]
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[[Category: Large Structures]]
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[[Category: Escherichia coli k12]]
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[[Category: Hemmings AM]]
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[[Category: Hemmings, A M.]]
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[[Category: Kleanthous C]]
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[[Category: Kleanthous, C.]]
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[[Category: Kolade OO]]
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[[Category: Kolade, O O.]]
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[[Category: Kuhlmann UC]]
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[[Category: Kuhlmann, U C.]]
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[[Category: Santi PS]]
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[[Category: Santi, P S.]]
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[[Category: 4-helix bundle]]
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[[Category: Antibiotic-antibiotic inhibitor complex]]
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[[Category: Dnase domain]]
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[[Category: Hnh-motif]]
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[[Category: Protein-protein complex]]
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Current revision

Crystal Structure of the E9 DNase Domain with a Mutant Immunity Protein IM9 (V34A)

PDB ID 2gzi

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