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2h4u

From Proteopedia

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[[Image:2h4u.png|left|200px]]
 
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{{STRUCTURE_2h4u| PDB=2h4u | SCENE= }}
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==Crystal Structure of Human Thioesterase Superfamily Member 2 (CASP Target)==
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<StructureSection load='2h4u' size='340' side='right'caption='[[2h4u]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Crystal Structure of Human Thioesterase Superfamily Member 2 (CASP Target)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2h4u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H4U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4u OCA], [https://pdbe.org/2h4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h4u RCSB], [https://www.ebi.ac.uk/pdbsum/2h4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h4u ProSAT]</span></td></tr>
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[[2h4u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4U OCA].
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</table>
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[[Category: Acetyl-CoA hydrolase]]
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== Function ==
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[https://www.uniprot.org/uniprot/ACO13_HUMAN ACO13_HUMAN] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h4/2h4u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h4u ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Berglund, H.]]
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[[Category: Arrowsmith C]]
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[[Category: Edwards, A.]]
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[[Category: Berglund H]]
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[[Category: Ehn, M.]]
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[[Category: Edwards A]]
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[[Category: Flodin, S.]]
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[[Category: Ehn M]]
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[[Category: Grasslund, S.]]
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[[Category: Flodin S]]
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[[Category: Hallberg, M.]]
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[[Category: Grasslund S]]
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[[Category: Hammerstrom, M.]]
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[[Category: Hallberg M]]
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[[Category: Hogbom, M.]]
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[[Category: Hammerstrom M]]
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[[Category: Holmberg-Schiavone, L.]]
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[[Category: Hogbom M]]
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[[Category: Kotenyova, T.]]
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[[Category: Holmberg-Schiavone L]]
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[[Category: Nilsson-Ehle, P.]]
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[[Category: Kotenyova T]]
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[[Category: Nordlund, P.]]
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[[Category: Nilsson-Ehle P]]
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[[Category: Nyman, T.]]
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[[Category: Nordlund P]]
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[[Category: Ogg, D J.]]
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[[Category: Nyman T]]
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[[Category: Persson, C.]]
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[[Category: Ogg DJ]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Persson C]]
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[[Category: Sagemark, J.]]
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[[Category: Sagemark J]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Thorsell, A G.]]
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[[Category: Thorsell A-G]]
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[[Category: Uppenberg, J.]]
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[[Category: Uppenberg J]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Hydrolase]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Thioesterase]]
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Current revision

Crystal Structure of Human Thioesterase Superfamily Member 2 (CASP Target)

PDB ID 2h4u

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